@article{acb569c21a7f4ab189e392ab13c2b000,
title = "How OSA Evolves From Childhood to Young Adulthood: Natural History From a 10-Year Follow-up Study",
abstract = "Background: Understanding the natural history of childhood OSA can help to determine disease prognosis and to guide risk stratification and management strategies. Methods: To evaluate the natural history of childhood OSA and factors associated with spontaneous remission and persistent and incident OSA from childhood to late adolescence/early adulthood, a longitudinal analysis of a prospective community-based cohort was designed. Subjects from a cohort established for an OSA prevalence study were invited to participate in this 10-year follow-up study. Results: Two hundred and forty-three participants (59% male) took part, and their mean age was 9.8 (SD, ± 1.8) and 20.2 (SD, ± 1.9) years at baseline and follow-up, respectively. The mean follow-up duration was 10.4 (SD, ± 1.1) years. Associations between baseline and follow-up log-transformed obstructive apnea-hypopnea index (OAHI) differed by age; a significant positive association was observed only among participants aged 10 years or older at baseline. Overall polysomnographic remission rate (with OAHI < 1 event/h at follow-up) of childhood OSA was 30%, and 69% had an OAHI < 5 events/h at follow-up. Complete remission of OSA was associated with female sex. Incidence of adolescent/adult OSA with an OAHI ≥ 5 events/h at follow-up was 22%. Male sex and higher baseline BMI z score were associated with incident OSA. Conclusions: A proportion of children with OSA, particularly female children, had complete resolution during transition to late adolescence or early adulthood. Childhood and adolescent OSA are distinct entities, with the latter more likely to persist into adulthood. Obesity and male sex are consistent key risk factors for incident OSA.",
keywords = "children, longitudinal study, natural history, sleep apnea",
author = "Chan, {Kate C.} and Au, {Chun T.} and Hui, {L. L.} and Ng, {Siu kwan} and Wing, {Yun K.} and Li, {Albert M.}",
note = "Funding Information: Author contributions: The lead author, K. C. C. affirms that the manuscript is an honest, accurate, and transparent account of the study being reported; and that no important aspects of the study have been omitted. K. C. C. conceptualized and designed the study, coordinated subject recruitment and performed data collection, carried out the data analysis and interpretation, drafted the initial report, and revised and approved the final report as submitted. C. T. A. conceptualized and designed the study, coordinated subject recruitment and performed data collection, carried out the data analysis and interpretation, and revised and approved the final report as submitted. L. L. H. designed the study, carried out the data analysis and interpretation, and revised and approved the final report as submitted. S. K. N. designed the study, performed data collection, and revised and approved the final report as submitted. Y. K. W. conceptualized and designed the study, and revised and approved the final report as submitted. A. M. L. conceptualized and designed the study, coordinated subject recruitment and performed data collection, carried out the data interpretation, and revised and approved the final report as submitted. Financial/nonfinancial disclosures: None declared. Role of sponsors: The sponsor had no role in the design of the study, the collection and analysis of the data, or the preparation of the manuscript. Other contributions: The authors thank all the participants and their parents for their contribution in this study. Additional information: The e-Appendix and e-Table can be found in the Supplemental Materials section of the online article. FUNDING/SUPPORT: This research project was supported by funding from the Research Grants Council of the Hong Kong Special Administrative Region, China [CUHK 470913]. Funding Information: FUNDING/SUPPORT: This research project was supported by funding from the Research Grants Council of the Hong Kong Special Administrative Region, China [CUHK 470913]. Publisher Copyright: {\textcopyright} 2019 American College of Chest Physicians",
year = "2019",
month = jul,
doi = "10.1016/j.chest.2019.03.007",
language = "English",
volume = "156",
pages = "120--130",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "1",
}