TY - JOUR
T1 - Homotopy of resting-state functional connectivity correlates with psychological distress in adolescent and young adult cancer patients
AU - Xie, Jianfei
AU - Li, Lijun
AU - Wang, Lu
AU - Xiao, Panpan
AU - Liu, Jin
AU - Liu, Xiangyu
AU - Zhou, Jianda
AU - Liao, Yunjie
AU - Cheng, Andy S.K.
N1 - Funding Information:
We would like thanks to Wisdom Accumulation and Talent Cultivation Project, National Natural Science Foundation of China and Fundamental Research Funds for the Central Universities of Central South University fund project for their finical supports. And grateful to all participants for their voluntary participation and all the members of our research team.
Funding Information:
Paper supported by the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University (NO. YX202006); The National Natural Science Foundation of China (NO. 82073409); Fundamental Research Funds for the Central Universities of Central South University (No. 2020zzts841).
Publisher Copyright:
© 2021 The Author(s).
PY - 2021/12/30
Y1 - 2021/12/30
N2 - Background: Adolescent and young adult cancer patients (AYACPs) experience a high incidence of psychological distress. However, the effect of psychological distress on the functional connectivity between the hemispheres in AYACPs remains unknown. Voxel-mirrored homotopy connectivity detection is an effective way to explore the effects of psychological distress on functional connectivity throughout the brain in AYACPs. Methods: Twenty-four AYACPs underwent structural magnetic resonance imaging. Results: Voxel-mirrored homotopy connectivity in the psychological distress group was significantly lower in the superior parietal gyrus, middle frontal gyrus (orbital part), superior frontal gyrus (dorsolateral), superior occipital gyrus, precuneus, lingual gyrus, calcarine fissure and surrounding cortex than in the non-psychological distress group, while in the inferior temporal gyrus and middle frontal gyrus (orbital part), voxel-mirrored homotopy connectivity was significantly higher (p < 0.05). ROC curve analysis showed that the decrease in voxel-mirrored homotopy connectivity in the following brain regions was helpful in distinguishing the psychological distress group from the non-psychological distress group: left superior frontal gyrus (dorsolateral), left calcarine fissure and surrounding cortex, right postcentral gyrus, and left precuneus. Conclusions: Activity imbalances in multiple brain regions exist in AYACPs with psychological distress. Voxel-mirrored homotopy connectivity detection is an effective way to explore the potential neural mechanisms of mental disorders in AYACPs and optimize the treatment of mental disorders.
AB - Background: Adolescent and young adult cancer patients (AYACPs) experience a high incidence of psychological distress. However, the effect of psychological distress on the functional connectivity between the hemispheres in AYACPs remains unknown. Voxel-mirrored homotopy connectivity detection is an effective way to explore the effects of psychological distress on functional connectivity throughout the brain in AYACPs. Methods: Twenty-four AYACPs underwent structural magnetic resonance imaging. Results: Voxel-mirrored homotopy connectivity in the psychological distress group was significantly lower in the superior parietal gyrus, middle frontal gyrus (orbital part), superior frontal gyrus (dorsolateral), superior occipital gyrus, precuneus, lingual gyrus, calcarine fissure and surrounding cortex than in the non-psychological distress group, while in the inferior temporal gyrus and middle frontal gyrus (orbital part), voxel-mirrored homotopy connectivity was significantly higher (p < 0.05). ROC curve analysis showed that the decrease in voxel-mirrored homotopy connectivity in the following brain regions was helpful in distinguishing the psychological distress group from the non-psychological distress group: left superior frontal gyrus (dorsolateral), left calcarine fissure and surrounding cortex, right postcentral gyrus, and left precuneus. Conclusions: Activity imbalances in multiple brain regions exist in AYACPs with psychological distress. Voxel-mirrored homotopy connectivity detection is an effective way to explore the potential neural mechanisms of mental disorders in AYACPs and optimize the treatment of mental disorders.
KW - AYACPs
KW - Cancer
KW - Functional neuroimaging
KW - Psychological distress
KW - Resting-state
UR - http://www.scopus.com/inward/record.url?scp=85123076025&partnerID=8YFLogxK
U2 - 10.52586/5041
DO - 10.52586/5041
M3 - Journal article
C2 - 34994162
AN - SCOPUS:85123076025
SN - 2768-6701
VL - 26
SP - 1470
EP - 1479
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
IS - 12
ER -
