Homogeneous sulfation of bagasse cellulose in an ionic liquid and anticoagulation activity

Zhao Mei Wang; Lin Li; Kai Jun Xiao; Jianyong Wu

doi:10.1016/j.biortech.2008.09.002

Homogeneous sulfation of bagasse cellulose in an ionic liquid and anticoagulation activity

Zhao Mei Wang, Lin Li, Kai Jun Xiao, Jianyong Wu

Research output: Journal article publication › Journal article › Academic research › peer-review

80 Citations (Scopus)

Abstract

Homogeneous sulfation of bagasse cellulose (BC) with chlorosulfonic acid-dimethylformamide was accomplished in an ionic liquid 1-butyl-3-methylimidazolium chloride ([C4mim]Cl). The BCS products from the sulfation had degrees of substitution (DS) in the range of 0.52-2.95 and a simultaneous substitution pattern at C-6, C-2 and C-3 positions. The sulfated BCS attained significant anticoagulation activity, causing a dose-dependent prolongation of coagulation time and inhibition of FIIa and FXa activities in human plasma. The anticoagulation activity of BCS showed a positive correlation with DS, and some of the activity indexes exceeded those of heparin.

Original language	English
Pages (from-to)	1687-1690
Number of pages	4
Journal	Bioresource Technology
Volume	100
Issue number	4
DOIs	https://doi.org/10.1016/j.biortech.2008.09.002
Publication status	Published - 1 Feb 2009

Keywords

Anticoagulation
Bagasse cellulose sulfates
Degree of substitution
Ionic liquid
Sugarcane bagasse

ASJC Scopus subject areas

Bioengineering
Environmental Engineering
Waste Management and Disposal

More information

10.1016/j.biortech.2008.09.002

Cite this

@article{14e33d1d17734eab90bffe836072cce6,

title = "Homogeneous sulfation of bagasse cellulose in an ionic liquid and anticoagulation activity",

abstract = "Homogeneous sulfation of bagasse cellulose (BC) with chlorosulfonic acid-dimethylformamide was accomplished in an ionic liquid 1-butyl-3-methylimidazolium chloride ([C4mim]Cl). The BCS products from the sulfation had degrees of substitution (DS) in the range of 0.52-2.95 and a simultaneous substitution pattern at C-6, C-2 and C-3 positions. The sulfated BCS attained significant anticoagulation activity, causing a dose-dependent prolongation of coagulation time and inhibition of FIIa and FXa activities in human plasma. The anticoagulation activity of BCS showed a positive correlation with DS, and some of the activity indexes exceeded those of heparin.",

keywords = "Anticoagulation, Bagasse cellulose sulfates, Degree of substitution, Ionic liquid, Sugarcane bagasse",

author = "Wang, {Zhao Mei} and Lin Li and Xiao, {Kai Jun} and Jianyong Wu",

year = "2009",

month = feb,

day = "1",

doi = "10.1016/j.biortech.2008.09.002",

language = "English",

volume = "100",

pages = "1687--1690",

journal = "Bioresource Technology",

issn = "0960-8524",

publisher = "Elsevier Ltd",

number = "4",

}

TY - JOUR

T1 - Homogeneous sulfation of bagasse cellulose in an ionic liquid and anticoagulation activity

AU - Wang, Zhao Mei

AU - Li, Lin

AU - Xiao, Kai Jun

AU - Wu, Jianyong

PY - 2009/2/1

Y1 - 2009/2/1

N2 - Homogeneous sulfation of bagasse cellulose (BC) with chlorosulfonic acid-dimethylformamide was accomplished in an ionic liquid 1-butyl-3-methylimidazolium chloride ([C4mim]Cl). The BCS products from the sulfation had degrees of substitution (DS) in the range of 0.52-2.95 and a simultaneous substitution pattern at C-6, C-2 and C-3 positions. The sulfated BCS attained significant anticoagulation activity, causing a dose-dependent prolongation of coagulation time and inhibition of FIIa and FXa activities in human plasma. The anticoagulation activity of BCS showed a positive correlation with DS, and some of the activity indexes exceeded those of heparin.

AB - Homogeneous sulfation of bagasse cellulose (BC) with chlorosulfonic acid-dimethylformamide was accomplished in an ionic liquid 1-butyl-3-methylimidazolium chloride ([C4mim]Cl). The BCS products from the sulfation had degrees of substitution (DS) in the range of 0.52-2.95 and a simultaneous substitution pattern at C-6, C-2 and C-3 positions. The sulfated BCS attained significant anticoagulation activity, causing a dose-dependent prolongation of coagulation time and inhibition of FIIa and FXa activities in human plasma. The anticoagulation activity of BCS showed a positive correlation with DS, and some of the activity indexes exceeded those of heparin.

KW - Anticoagulation

KW - Bagasse cellulose sulfates

KW - Degree of substitution

KW - Ionic liquid

KW - Sugarcane bagasse

UR - http://www.scopus.com/inward/record.url?scp=56249090736&partnerID=8YFLogxK

U2 - 10.1016/j.biortech.2008.09.002

DO - 10.1016/j.biortech.2008.09.002

M3 - Journal article

C2 - 18973999

SN - 0960-8524

VL - 100

SP - 1687

EP - 1690

JO - Bioresource Technology

JF - Bioresource Technology

IS - 4

ER -

Homogeneous sulfation of bagasse cellulose in an ionic liquid and anticoagulation activity

Abstract

Keywords

ASJC Scopus subject areas

More information

Other files and links

Fingerprint

Cite this