Homogeneous sulfation of bagasse cellulose in an ionic liquid and anticoagulation activity

Zhao Mei Wang, Lin Li, Kai Jun Xiao, Jianyong Wu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

78 Citations (Scopus)


Homogeneous sulfation of bagasse cellulose (BC) with chlorosulfonic acid-dimethylformamide was accomplished in an ionic liquid 1-butyl-3-methylimidazolium chloride ([C4mim]Cl). The BCS products from the sulfation had degrees of substitution (DS) in the range of 0.52-2.95 and a simultaneous substitution pattern at C-6, C-2 and C-3 positions. The sulfated BCS attained significant anticoagulation activity, causing a dose-dependent prolongation of coagulation time and inhibition of FIIa and FXa activities in human plasma. The anticoagulation activity of BCS showed a positive correlation with DS, and some of the activity indexes exceeded those of heparin.
Original languageEnglish
Pages (from-to)1687-1690
Number of pages4
JournalBioresource Technology
Issue number4
Publication statusPublished - 1 Feb 2009


  • Anticoagulation
  • Bagasse cellulose sulfates
  • Degree of substitution
  • Ionic liquid
  • Sugarcane bagasse

ASJC Scopus subject areas

  • Bioengineering
  • Environmental Engineering
  • Waste Management and Disposal


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