Hippocampal α5 subunit-containing GABAAreceptors are involved in the development of the latent inhibition effect

T. V. Gerdjikov, U. Rudolph, R. Keist, H. Möhler, J. Feldon, Kay Yan Benjamin Yee

Research output: Journal article publicationJournal articleAcademic researchpeer-review

33 Citations (Scopus)

Abstract

Hippocampal GABAAreceptors containing the α5 subunit have been implicated in the modulation of hippocampal-dependent learning, presumably via their tonic inhibitory influence on hippocampal glutamatergic activity. Here, we examined the expression of latent inhibition (LI)-a form of selective learning that is sensitive to a number of manipulations targeted at the hippocampal formation, in α5(H105R) mutant mice with reduced levels of hippocampal α5-containing GABAAreceptors. A single pre-exposure to the taste conditioned stimulus (CS) prior to the pairing of the same CS with LiCl-induced nausea was effective in reducing the conditioned aversion against the taste CS in wild-type mice-thus constituting the LI effect. LI was however distinctly absent in male α5(H105R) mutant mice. Hence, a partial loss of hippocampal α5 GABAAreceptors is sufficient to alter one major form of selective learning, albeit this was not seen in the female. This observed phenotype suggests that specific activation of these extrasynaptic GABAAreceptors may confer therapeutic potential against the failure to show selectivity in learning by human psychotic patients.
Original languageEnglish
Pages (from-to)87-94
Number of pages8
JournalNeurobiology of Learning and Memory
Volume89
Issue number2
DOIs
Publication statusPublished - 1 Feb 2008
Externally publishedYes

Keywords

  • Attention
  • Benzodiazepine
  • Conditioned taste aversion
  • GABA
  • Learning
  • Schizophrenia

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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