Hip Fracture as a Predictive Marker for the Risk of Dementia: A Population-Based Cohort Study

Warrington W.Q. Hsu; Xiaowen Zhang; Chor Wing Sing; Gloria H.Y. Li; Kathryn C.B. Tan; Annie W.C. Kung; Janus S.H. Wong; Ian Chi Kei Wong; Ching Lung Cheung

doi:10.1016/j.jamda.2022.07.013

Hip Fracture as a Predictive Marker for the Risk of Dementia: A Population-Based Cohort Study

Warrington W.Q. Hsu, Xiaowen Zhang, Chor Wing Sing, Gloria H.Y. Li, Kathryn C.B. Tan, Annie W.C. Kung, Janus S.H. Wong, Ian Chi Kei Wong, Ching Lung Cheung

Research output: Journal article publication › Journal article › Academic research › peer-review

6 Citations (Scopus)

Abstract

Objectives: This study aimed to investigate the association between hip fracture and the risk of dementia. Design: A retrospective real-world propensity score–matched cohort study was conducted using the real-world hip fracture cohort (RHFC). Setting and Participants: Electronic health record data from the Clinical Data Analysis and Reporting System (CDARS) in Hong Kong were used. A total of 52,848 patients aged ≥65 years and with at least an event of fall from 2006 to 2015 were included in the RHFC. Methods: The incidence of fall, hip fracture, and dementia was determined using their International Classification of Diseases, Ninth Revision (ICD-9) codes. Competing risk regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results: Hip fracture was associated with an increased risk of dementia (HR 1.09, 95% CI 1.04-1.15, P < .001). The subgroup analysis showed that association was significant in women but not in men. Conclusions and Implications: Hip fracture was associated with the increased risk of dementia among older adults. Further studies investigating the potential roles of hip fracture in the development of dementia could benefit the management of both conditions in older adults.

Original language	English
Pages (from-to)	1720.e1-1720.e9
Journal	Journal of the American Medical Directors Association
Volume	23
Issue number	10
DOIs	https://doi.org/10.1016/j.jamda.2022.07.013
Publication status	Published - Oct 2022

Keywords

dementia
Epidemiology
hip fracture
osteoporosis

ASJC Scopus subject areas

General Nursing
Health Policy
Geriatrics and Gerontology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1016/j.jamda.2022.07.013

Cite this

@article{844b1843171b4185838e12865457bf1c,

title = "Hip Fracture as a Predictive Marker for the Risk of Dementia: A Population-Based Cohort Study",

abstract = "Objectives: This study aimed to investigate the association between hip fracture and the risk of dementia. Design: A retrospective real-world propensity score–matched cohort study was conducted using the real-world hip fracture cohort (RHFC). Setting and Participants: Electronic health record data from the Clinical Data Analysis and Reporting System (CDARS) in Hong Kong were used. A total of 52,848 patients aged ≥65 years and with at least an event of fall from 2006 to 2015 were included in the RHFC. Methods: The incidence of fall, hip fracture, and dementia was determined using their International Classification of Diseases, Ninth Revision (ICD-9) codes. Competing risk regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results: Hip fracture was associated with an increased risk of dementia (HR 1.09, 95% CI 1.04-1.15, P < .001). The subgroup analysis showed that association was significant in women but not in men. Conclusions and Implications: Hip fracture was associated with the increased risk of dementia among older adults. Further studies investigating the potential roles of hip fracture in the development of dementia could benefit the management of both conditions in older adults.",

keywords = "dementia, Epidemiology, hip fracture, osteoporosis",

author = "Hsu, {Warrington W.Q.} and Xiaowen Zhang and Sing, {Chor Wing} and Li, {Gloria H.Y.} and Tan, {Kathryn C.B.} and Kung, {Annie W.C.} and Wong, {Janus S.H.} and Wong, {Ian Chi Kei} and Cheung, {Ching Lung}",

note = "Funding Information: This work was supported by AIR@InnoHK administered by Innovation and Technology Commission. Funding Information: Funding: The study received funding support from the Health and Medical Research Fund, Food and Health Bureau , The Government of the Hong Kong Special Administrative Region (reference 18192451). Publisher Copyright: {\textcopyright} 2022 AMDA – The Society for Post-Acute and Long-Term Care Medicine",

year = "2022",

month = oct,

doi = "10.1016/j.jamda.2022.07.013",

language = "English",

volume = "23",

pages = "1720.e1--1720.e9",

journal = "Journal of the American Medical Directors Association",

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T1 - Hip Fracture as a Predictive Marker for the Risk of Dementia

T2 - A Population-Based Cohort Study

AU - Hsu, Warrington W.Q.

AU - Zhang, Xiaowen

AU - Sing, Chor Wing

AU - Li, Gloria H.Y.

AU - Tan, Kathryn C.B.

AU - Kung, Annie W.C.

AU - Wong, Janus S.H.

AU - Wong, Ian Chi Kei

AU - Cheung, Ching Lung

N1 - Funding Information: This work was supported by AIR@InnoHK administered by Innovation and Technology Commission. Funding Information: Funding: The study received funding support from the Health and Medical Research Fund, Food and Health Bureau , The Government of the Hong Kong Special Administrative Region (reference 18192451). Publisher Copyright: © 2022 AMDA – The Society for Post-Acute and Long-Term Care Medicine

PY - 2022/10

Y1 - 2022/10

N2 - Objectives: This study aimed to investigate the association between hip fracture and the risk of dementia. Design: A retrospective real-world propensity score–matched cohort study was conducted using the real-world hip fracture cohort (RHFC). Setting and Participants: Electronic health record data from the Clinical Data Analysis and Reporting System (CDARS) in Hong Kong were used. A total of 52,848 patients aged ≥65 years and with at least an event of fall from 2006 to 2015 were included in the RHFC. Methods: The incidence of fall, hip fracture, and dementia was determined using their International Classification of Diseases, Ninth Revision (ICD-9) codes. Competing risk regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results: Hip fracture was associated with an increased risk of dementia (HR 1.09, 95% CI 1.04-1.15, P < .001). The subgroup analysis showed that association was significant in women but not in men. Conclusions and Implications: Hip fracture was associated with the increased risk of dementia among older adults. Further studies investigating the potential roles of hip fracture in the development of dementia could benefit the management of both conditions in older adults.

AB - Objectives: This study aimed to investigate the association between hip fracture and the risk of dementia. Design: A retrospective real-world propensity score–matched cohort study was conducted using the real-world hip fracture cohort (RHFC). Setting and Participants: Electronic health record data from the Clinical Data Analysis and Reporting System (CDARS) in Hong Kong were used. A total of 52,848 patients aged ≥65 years and with at least an event of fall from 2006 to 2015 were included in the RHFC. Methods: The incidence of fall, hip fracture, and dementia was determined using their International Classification of Diseases, Ninth Revision (ICD-9) codes. Competing risk regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results: Hip fracture was associated with an increased risk of dementia (HR 1.09, 95% CI 1.04-1.15, P < .001). The subgroup analysis showed that association was significant in women but not in men. Conclusions and Implications: Hip fracture was associated with the increased risk of dementia among older adults. Further studies investigating the potential roles of hip fracture in the development of dementia could benefit the management of both conditions in older adults.

KW - dementia

KW - Epidemiology

KW - hip fracture

KW - osteoporosis

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SN - 1525-8610

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JO - Journal of the American Medical Directors Association

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ER -

Hip Fracture as a Predictive Marker for the Risk of Dementia: A Population-Based Cohort Study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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