Highly enantioselective iridium-catalyzed hydrogenation of quinoline derivatives using chiral phosphinite H8-BINAPO

Hung Lam Kim, Lijin Xu, Lichun Feng, Qing Hua Fan, Loi Lam Fuk, Wai Hung Lo, Albert S.C. Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

109 Citations (Scopus)


The chiral diphosphinite H8-BINAPO derived from H8-BINOL has been used in the Ir-catalyzed asymmetric hydrogenation of quinolines, and high enantioselectivity (up to 97% ee) was obtained. Immobilization of the iridium catalyst in poly(ethylene glycol) dimethyl ether (DMPEG) is also discussed. With DMPEG/hexane biphasic system, better enantioselectivities were obtained as compared to those observed in aprotic organic solvents. KGaA.
Original languageEnglish
Pages (from-to)1755-1758
Number of pages4
JournalAdvanced Synthesis and Catalysis
Issue number14
Publication statusPublished - 1 Nov 2005


  • Asymmetric hydrogenation
  • Immobilization
  • Iridium
  • Phosphinite ligands
  • Poly(ethylene glycol) dimethyl ether
  • Quinoline

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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