Highly enantioselective hydrogenation of enamides catalyzed by rhodium-monodentate phosphoramidite complex derived from H8-BINOL

Xingshu Li, Xian Jia, Gui Lu, Terry T.L. Au-Yeung, Kim Hung Lam, Wai Hung Lo, Albert S.C. Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

37 Citations (Scopus)

Abstract

A series of monodentate phosphoramidite ligands derived from H8-BINOL have been synthesized. The ligands are used in the Rh-catalyzed asymmetric hydrogenation of enamides to give the acetamides in up to 99% ee.
Original languageEnglish
Pages (from-to)2687-2691
Number of pages5
JournalTetrahedron Asymmetry
Volume14
Issue number18
DOIs
Publication statusPublished - 19 Sep 2003

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this