Highly efficient synthesis of the tricyclic core of taxol by cascade metathesis

Aurélien Letort; Rémi Aouzal; Cong Ma; De Liang Long; Joëlle Prunet

doi:10.1021/ol501304j

Highly efficient synthesis of the tricyclic core of taxol by cascade metathesis

Aurélien Letort, Rémi Aouzal, Cong Ma, De Liang Long, Joëlle Prunet

Research output: Journal article publication › Journal article › Academic research › peer-review

21 Citations (Scopus)

Abstract

An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.

Original language	English
Pages (from-to)	3300-3303
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	12
DOIs	https://doi.org/10.1021/ol501304j
Publication status	Published - 20 Jun 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

More information

10.1021/ol501304j

Cite this

@article{c117ec520a1645b29538d781738c11ab,

title = "Highly efficient synthesis of the tricyclic core of taxol by cascade metathesis",

abstract = "An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.",

author = "Aur{\'e}lien Letort and R{\'e}mi Aouzal and Cong Ma and Long, \{De Liang\} and Jo{\"e}lle Prunet",

year = "2014",

month = jun,

day = "20",

doi = "10.1021/ol501304j",

language = "English",

volume = "16",

pages = "3300--3303",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "12",

}

TY - JOUR

T1 - Highly efficient synthesis of the tricyclic core of taxol by cascade metathesis

AU - Letort, Aurélien

AU - Aouzal, Rémi

AU - Ma, Cong

AU - Long, De Liang

AU - Prunet, Joëlle

PY - 2014/6/20

Y1 - 2014/6/20

N2 - An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.

AB - An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.

UR - https://www.scopus.com/pages/publications/84903201870

U2 - 10.1021/ol501304j

DO - 10.1021/ol501304j

M3 - Journal article

C2 - 24901765

SN - 1523-7060

VL - 16

SP - 3300

EP - 3303

JO - Organic Letters

JF - Organic Letters

IS - 12

ER -

Highly efficient synthesis of the tricyclic core of taxol by cascade metathesis

Abstract

ASJC Scopus subject areas

More information

Other files and links

Fingerprint

Cite this