Highly efficient synthesis of the tricyclic core of taxol by cascade metathesis

Aurélien Letort; Rémi Aouzal; Cong Ma; De Liang Long; Joëlle Prunet

doi:10.1021/ol501304j

Highly efficient synthesis of the tricyclic core of taxol by cascade metathesis

Aurélien Letort, Rémi Aouzal, Cong Ma, De Liang Long, Joëlle Prunet

Research output: Journal article publication › Journal article › Academic research › peer-review

21 Citations (Scopus)

Abstract

An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.

Original language	English
Pages (from-to)	3300-3303
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	12
DOIs	https://doi.org/10.1021/ol501304j
Publication status	Published - 20 Jun 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol501304j

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title = "Highly efficient synthesis of the tricyclic core of taxol by cascade metathesis",

abstract = "An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.",

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AU - Letort, Aurélien

AU - Aouzal, Rémi

AU - Ma, Cong

AU - Long, De Liang

AU - Prunet, Joëlle

PY - 2014/6/20

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AB - An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.

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U2 - 10.1021/ol501304j

DO - 10.1021/ol501304j

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JO - Organic Letters

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Highly efficient synthesis of the tricyclic core of taxol by cascade metathesis

Abstract

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