Highly efficient synthesis of the tricyclic core of taxol by cascade metathesis

Aurélien Letort, Rémi Aouzal, Cong Ma, De Liang Long, Joëlle Prunet

Research output: Journal article publicationJournal articleAcademic researchpeer-review

13 Citations (Scopus)


An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.
Original languageEnglish
Pages (from-to)3300-3303
Number of pages4
JournalOrganic Letters
Issue number12
Publication statusPublished - 20 Jun 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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