High performance shape memory foams with isocyanate-modified hydroxyapatite nanoparticles for minimally invasive bone regeneration

Ruiqi Xie, Jinlian Hu, Man Ching Frankie Ng, Lin Tan, Tingwu Qin, Mingqiu Zhang, Xia Guo

Research output: Journal article publicationJournal articleAcademic researchpeer-review

28 Citations (Scopus)


This study conducts a comprehensive assessment of shape memory polyurethane (SMPU) composite foams with isocyanate-modified hydroxyapatite (imHA) nanoparticles in terms of their pore structures, mechanical properties, shape memory effects and biocompatibility in vitro. The results obtained in the research reveal the effectiveness of imHA nanoparticles in SMPU foams as inorganic cross-linking fillers, which contribute to the enhancement of mechanical properties and shape memory performance. Pore structures and compressive properties are simultaneously optimized when imHA content increases. The imHA enhanced SMPU foam could be adopted as a promising alternative for overcoming the disadvantages of traditional polymer scaffolds, such as insufficient mechanical properties, inadequate pore structure, low bioactivity and inconvenience in operation for bone regeneration.
Original languageEnglish
Pages (from-to)4794-4802
Number of pages9
JournalCeramics International
Issue number6
Publication statusPublished - 15 Apr 2017


  • A. Composites
  • B. Mechanical properties
  • B. Thermomechanical properties
  • Isocyanate-modified hydroxyapatite

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Process Chemistry and Technology
  • Surfaces, Coatings and Films
  • Materials Chemistry

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