TY - JOUR
T1 - High myopia induced by form deprivation is associated with altered corneal biomechanical properties in chicks
AU - Soo Kang, Byung
AU - Wang, Li Ke
AU - Zheng, Yong Ping
AU - Guggenheim, Jeremy A.
AU - Stell, William K.
AU - Kee, Chea su
PY - 2018/11
Y1 - 2018/11
N2 - The cornea is a soft, transparent, composite organic tissue, which forms the anterior outer coat of the eyeball. Although high myopia is increasing in prevalence worldwide and is known to alter the structure and biomechanical properties of the sclera, remarkably little is known about its impact on the biomechanics of the cornea. We developed and validated a novel optical-coherence-tomography-indentation probe–to measure corneal biomechanical properties in situ, in chicks having experimentally-induced high myopia, while maintaining intraocular pressure at levels covering the physiological range. We found that the cornea of highly myopic chicks was more steeply curved and softer, at all tested intraocular pressures, than that in contralateral, non-myopic eyes, or in age-matched normal, untreated eyes. These results indicate that the biomechanical properties of the cornea are altered in chicks developing experimentally-induced myopia.
AB - The cornea is a soft, transparent, composite organic tissue, which forms the anterior outer coat of the eyeball. Although high myopia is increasing in prevalence worldwide and is known to alter the structure and biomechanical properties of the sclera, remarkably little is known about its impact on the biomechanics of the cornea. We developed and validated a novel optical-coherence-tomography-indentation probe–to measure corneal biomechanical properties in situ, in chicks having experimentally-induced high myopia, while maintaining intraocular pressure at levels covering the physiological range. We found that the cornea of highly myopic chicks was more steeply curved and softer, at all tested intraocular pressures, than that in contralateral, non-myopic eyes, or in age-matched normal, untreated eyes. These results indicate that the biomechanical properties of the cornea are altered in chicks developing experimentally-induced myopia.
UR - http://www.scopus.com/inward/record.url?scp=85056359228&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0207189
DO - 10.1371/journal.pone.0207189
M3 - Journal article
C2 - 30419001
AN - SCOPUS:85056359228
VL - 13
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 11
M1 - e0207189
ER -