High myopia induced by form deprivation is associated with altered corneal biomechanical properties in chicks

Byung Soo Kang, Li Ke Wang, Yong Ping Zheng, Jeremy A. Guggenheim, William K. Stell, Chea su Kee

Research output: Journal article publicationJournal articleAcademic researchpeer-review

11 Citations (Scopus)


The cornea is a soft, transparent, composite organic tissue, which forms the anterior outer coat of the eyeball. Although high myopia is increasing in prevalence worldwide and is known to alter the structure and biomechanical properties of the sclera, remarkably little is known about its impact on the biomechanics of the cornea. We developed and validated a novel optical-coherence-tomography-indentation probe–to measure corneal biomechanical properties in situ, in chicks having experimentally-induced high myopia, while maintaining intraocular pressure at levels covering the physiological range. We found that the cornea of highly myopic chicks was more steeply curved and softer, at all tested intraocular pressures, than that in contralateral, non-myopic eyes, or in age-matched normal, untreated eyes. These results indicate that the biomechanical properties of the cornea are altered in chicks developing experimentally-induced myopia.

Original languageEnglish
Article numbere0207189
JournalPLoS ONE
Issue number11
Publication statusPublished - Nov 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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