TY - JOUR
T1 - High-intensity interval training in patients with left ventricular assist devices
T2 - A pilot randomized controlled trial
AU - Moreno-Suarez, Ignacio
AU - Scheer, Anna
AU - Lam, Kaitlyn
AU - Dembo, Lawrence
AU - Spence, Angela L.
AU - Hayward, Christopher
AU - Kaye, David M.
AU - Leet, Angela
AU - Fuller, Louise M.
AU - Jacques, Angela
AU - Naylor, Louise H.
AU - Green, Daniel J.
AU - Maiorana, Andrew
N1 - Funding Information:
This project was supported by a Heart Foundation of Australia Vanguard Grant (101040). I.M.S. was supported by a PhD Scholarship funded by Curtin University and the Heart and Lung Transplant Foundation of Western Australia.
Publisher Copyright:
© 2020 International Society for Heart and Lung Transplantation
PY - 2020/12
Y1 - 2020/12
N2 - BACKGROUND: Left ventricular assist device (LVAD) implantation is an established treatment for patients with advanced heart failure. To date, studies evaluating the impact of aerobic training in patients with LVADs have focused on moderate-intensity exercise. METHODS: This pilot randomized controlled trial compared the effects of high-intensity interval training (HIIT) with those of moderate-intensity continuous training (MICT) on peak oxygen consumption (V̇O2 peak) in patients with LVADs. Secondary outcomes included 6-minute walk test distance, flow-mediated dilation, and anthropometry. Assessments were conducted at baseline and after 12 weeks of supervised training performed 3 times weekly. Participants were randomized to HIIT (4 sets of 4 minutes at 80%–90% V̇O2 reserve, alternating with 3 minutes at 50%–60% V̇O2 reserve) or MICT groups (28 minutes continuously at 50%–60% V̇O2 reserve). Within and between-group differences were analyzed using linear mixed models. Data are expressed as marginal means with 95% confidence intervals or as mean ± SD. RESULTS: A total of 21 participants were randomized (HIIT: age 57.7 ± 13.1 years; n = 11 and MICT: age 55.6 ± 14.2 years; n = 10) (mean ± SD). No major adverse events occurred in response to training in either group. HIIT significantly improved V̇O2 peak (15.6 [13.2–17.8] to 18.4 [16.0–20.8] ml/kg/min) (marginal mean [95% CI]) compared with MICT (16.2 [13.8–18.7] to 17.2 [14.6–19.7] ml/kg/min; p < 0.05 between groups). No significant group differences were detected in secondary outcomes. CONCLUSION: In patients with LVADs, HIIT was well tolerated and increased aerobic capacity more than MICT. These preliminary findings support the prescription of high-intensity exercise in clinically stable patients with LVADs but warrant validation in a larger sample and across a broader range of physiologic and clinical outcomes. CLINICAL TRIAL REGISTRATION: URL: https://www.anzctr.org.au, unique identifier: ACTRN12616001596493.
AB - BACKGROUND: Left ventricular assist device (LVAD) implantation is an established treatment for patients with advanced heart failure. To date, studies evaluating the impact of aerobic training in patients with LVADs have focused on moderate-intensity exercise. METHODS: This pilot randomized controlled trial compared the effects of high-intensity interval training (HIIT) with those of moderate-intensity continuous training (MICT) on peak oxygen consumption (V̇O2 peak) in patients with LVADs. Secondary outcomes included 6-minute walk test distance, flow-mediated dilation, and anthropometry. Assessments were conducted at baseline and after 12 weeks of supervised training performed 3 times weekly. Participants were randomized to HIIT (4 sets of 4 minutes at 80%–90% V̇O2 reserve, alternating with 3 minutes at 50%–60% V̇O2 reserve) or MICT groups (28 minutes continuously at 50%–60% V̇O2 reserve). Within and between-group differences were analyzed using linear mixed models. Data are expressed as marginal means with 95% confidence intervals or as mean ± SD. RESULTS: A total of 21 participants were randomized (HIIT: age 57.7 ± 13.1 years; n = 11 and MICT: age 55.6 ± 14.2 years; n = 10) (mean ± SD). No major adverse events occurred in response to training in either group. HIIT significantly improved V̇O2 peak (15.6 [13.2–17.8] to 18.4 [16.0–20.8] ml/kg/min) (marginal mean [95% CI]) compared with MICT (16.2 [13.8–18.7] to 17.2 [14.6–19.7] ml/kg/min; p < 0.05 between groups). No significant group differences were detected in secondary outcomes. CONCLUSION: In patients with LVADs, HIIT was well tolerated and increased aerobic capacity more than MICT. These preliminary findings support the prescription of high-intensity exercise in clinically stable patients with LVADs but warrant validation in a larger sample and across a broader range of physiologic and clinical outcomes. CLINICAL TRIAL REGISTRATION: URL: https://www.anzctr.org.au, unique identifier: ACTRN12616001596493.
KW - aerobic capacity
KW - anthropometry
KW - endothelial function
KW - exercise training
KW - high intensity
KW - left ventricular assist device
KW - six minute walk test
UR - http://www.scopus.com/inward/record.url?scp=85091203839&partnerID=8YFLogxK
U2 - 10.1016/j.healun.2020.08.005
DO - 10.1016/j.healun.2020.08.005
M3 - Journal article
C2 - 32958408
AN - SCOPUS:85091203839
SN - 1053-2498
VL - 39
SP - 1380
EP - 1388
JO - Journal of Heart and Lung Transplantation
JF - Journal of Heart and Lung Transplantation
IS - 12
ER -