High-frequency ultrasound microbeam induced calcium elevations in cancer cells: Discrimination between invasive and non-invasive breast cancer cells

Jae Youn Hwang, Nan Sook Lee, Changyang Lee, Kwok Ho Lam, Hyung Ham Kim, Qifa Zhou, Robert H. Chow, K. Kirk Shung

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

2 Citations (Scopus)


Breast cancer is the leading cancer in women. One of the most devastating events for the breast cancer patient is the transformation of a tumor from an indolent to an invasive state, which portends widespread metastasis. Thus, determination of the invasiveness of cancer tissues would be crucial to decide the aggressiveness of therapy. Our recent findings showed that invasive breast cancer cells, but not noninvasive breast cancer cells, express many neuron-like traits due to specific gene, thus enabling higher expression of ion channels that allow calcium ions (Ca2+) to enter cells. Therefore, in this paper, we tested whether high frequency ultrasound microbeam stimulates transient cytoplasmic Ca2+elevation preferentially in highly-invasive, but not weakly-invasive breast cancer cells, demonstrating the potential of high frequency ultrasound microbeam stimulation (HFUMS) for discrimination between invasive and weakly-invasive cancer cells.
Original languageEnglish
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Number of pages4
Publication statusPublished - 1 Dec 2012
Externally publishedYes
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: 7 Oct 201210 Oct 2012


Conference2012 IEEE International Ultrasonics Symposium, IUS 2012


  • breast cancer cells
  • calcium fluorescence imaging
  • high frequency ultrasound microbeam stimulation
  • invasiveness
  • mechanotransduction
  • metastasis

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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