High-frequency high frame rate ultrasound imaging system for small animal imaging with linear arrays

Xiao Chen Xu, Chang Hong Hu, Lei Sun, Jesse Yen, K. Kirk Shung

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

16 Citations (Scopus)


Due to the fast heart rate of a mouse greater than 400 beats/min, cardiovascular research utilizing mice requires imaging modalities with high frame rate capability (>100 Frames/sec), which cannot be realized by Micro-CT and Micro-PET at present. High-frequency ultrasound imaging, on the other hand, is capable of achieving a better spatial resolution at an affordable price. In this paper, we report the development of a high-frequency high frame rate ultrasound imaging system using 30-35MHz linear arrays. The system includes 64 pulsers, 16 1:4 De-multiplexers, 16 4:1 multiplexers, 16-channel TGC amplifiers, an analog beamforming board, a microprocessor (89S8252), a 500MS/s 8-bit PCI A/D card and a PC supported by Labview based software. The system can display 30 images per second and acquire over 100 images per second for slow motion playback with 30MHz 48 element linear arrays. Tissue mimicking phantoms were used to assess image quality. Rabbit eye images and mouse heart images have been obtained in vitro and in vivo to demonstrate the potential of this system in biomedical applications.
Original languageEnglish
Title of host publication2005 IEEE Ultrasonics Symposium
Number of pages4
Publication statusPublished - 1 Dec 2005
Externally publishedYes
Event2005 IEEE Ultrasonics Symposium - Rotterdam, Netherlands
Duration: 18 Sept 200521 Sept 2005


Conference2005 IEEE Ultrasonics Symposium


  • High frame rate
  • High-frequency ultrasound
  • Small animal imaging

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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