High-frequency duplex ultrasound imaging system for biomedical applications using 30 MHz linear arrays

Xiaochen Xu, Lequan Zhang, Lei Sun, Jesse T. Yen, Jonathan M. Cannata, K. Kirk Shung

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

1 Citation (Scopus)


High-frequency (HF) ultrasound imaging has been shown to be useful for imaging anatomical structures of the eye and small animals in biological and pharmaceutical research, achieving good spatial resolution at an affordable price. Cardiovascular research utilizing mice requires not only realtime B-scan imaging, but also ultrasound Doppler to evaluate both movements and blood flow of the mouse heart. In this paper, we report the development of the first real-time duplex HF ultrasound system with both B-scan imaging and Doppler imaging, using a 30 MHz 64-element linear array. The system included a HF pulsed-wave Doppler module, a 16-channel HF analog beamformer module, a PC with a 200MS/s 14-bit PCI A/D card, and real-time Labview software. Both a wire phantom and a micro flow phantom were used to evaluate system performance. The system has a lateral resolution better than 160 urn and is capable of measuring motion velocity as low as 0.1 mm/s and as high as 1 m/s. B-scan images of excised rabbit eyes have been achieved, as well as clear blood flow velocity profiles in mouse superficial vessels with diameters of 200 μm and major aortas. The system is able to acquire real-time B-mode and Doppler images. The system will also have the capability of acquiring >400 B-mode images per second. In vivo zebrafish and mouse experiment results show a promising future of this system in small animal research.
Original languageEnglish
Title of host publication2007 IEEE Ultrasonics Symposium Proceedings, IUS
Number of pages4
Publication statusPublished - 1 Dec 2007
Externally publishedYes
Event2007 IEEE Ultrasonics Symposium, IUS - New York, NY, United States
Duration: 28 Oct 200731 Oct 2007


Conference2007 IEEE Ultrasonics Symposium, IUS
Country/TerritoryUnited States
CityNew York, NY

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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