Heterogeneous Phase Transfer Catalysis in Solid Phase Syntheses of Anth-Cyclic Tetrapeptides

Dongyue Xin, Jian Yuan, Kwok Yin Wong, Kevin Burgess

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

This study features solid phase syntheses of cyclic tetrapeptides containing anthranilic acid (Anth) on relatively inexpensive resins derived from polystyrene. It proved to be difficult to hydrolyze a supported Anth-methyl ester unless a phase transfer catalyst was added to facilitate transport of hydroxide into the swollen hydrophobic gel state of the resin. We suggest this may be an under-appreciated strategy for improving syntheses on polystyrene supports.
Original languageEnglish
Pages (from-to)8077-8081
Number of pages5
JournalJournal of Organic Chemistry
Volume81
Issue number17
DOIs
Publication statusPublished - 2 Sep 2016

ASJC Scopus subject areas

  • Organic Chemistry

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