Heparin sulphate d-glucosaminyl 3-O-sulfotransferase 3B1 plays a role in HBV replication

Zhenzhen Zhang, Xiang Liu, Juan Chen, Huaibin Su, Qiang Luo, Jia Ye, Ni Tang, Wenlu Zhang, Wei Xian Chen, Chi Bun Ko, Ailong Huang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

15 Citations (Scopus)

Abstract

Hepatitis B virus infection is a worldwide epidemic and is closely associated with the development of hepatocellular carcinoma. Nevertheless, the molecular mechanisms of HBV infection and carcinogenesis remain elusive. Using a hepatocyte model of HBV infection and comparing the gene expression profiling analysis we found that heparan sulfate d-glucosaminyl 3-O-sulfotransferase 3 B1 (HS3ST3B1,3-OST3-B) is down-regulated in the hepatocytes of chronic HBV infection model. HS3ST3B1 showed potent inhibitory effect on HBV replication. The inhibitory effect of HS3ST3B1 overexpression was lost upon gene silencing of HS3ST3B1 or when a catalytic inactive mutant of HS3ST3B1 was expressed. Our study revealed the anti-viral activity of HS3ST3B1 on HBV replication. It is conceivable that possible therapeutic applications of HBV infection could be devised by manipulating HS3ST3B1 activity.
Original languageEnglish
Pages (from-to)280-285
Number of pages6
JournalVirology
Volume406
Issue number2
DOIs
Publication statusPublished - 1 Oct 2010
Externally publishedYes

Keywords

  • Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 B1
  • Hepatitis B virus
  • Inhibition
  • Replication

ASJC Scopus subject areas

  • Virology

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