Healthy dietary patterns and the risk of individual chronic diseases in community-dwelling adults

Xianwen Shang, Jiahao Liu, Zhuoting Zhu, Xueli Zhang, Yu Huang, Shunming Liu, Wei Wang, Xiayin Zhang, Shulin Tang, Yijun Hu, Honghua Yu, Zongyuan Ge, Guangdong Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University

Research output: Journal article publicationJournal articleAcademic researchpeer-review

3 Citations (Scopus)


It is unclear regarding associations of dietary patterns with a wide range of chronic diseases and which dietary score is more predictive of major chronic diseases. Using the UK Biobank, we examine associations of four individual healthy dietary scores with the risk of 48 individual chronic diseases. Higher Alternate Mediterranean Diet score is associated with a lower risk of 32 (all 8 cardiometabolic disorders, 3 out of 10 types of cancers, 7 out of 10 psychological/neurological disorders, 5 out of 6 digestive disorders, and 9 out of 14 other chronic diseases). Alternate Healthy Eating Index-2010 and Healthful Plant-based Diet Index are inversely associated with the risk of 29 and 23 individual chronic diseases, respectively. A higher Anti-Empirical Dietary Inflammatory Index is associated with a lower risk of 14 individual chronic diseases and a higher incidence of two diseases. Our findings support dietary guidelines for the prevention of most chronic diseases.
Original languageEnglish
Article number6704
Pages (from-to)1-14
Number of pages14
JournalNature Communications
Issue number1
Publication statusPublished - 23 Oct 2023


  • Alzheimer's disease
  • Cancer epidemiology
  • Peripheral vascular disease
  • Risk factors
  • Type 2 diabetes

ASJC Scopus subject areas

  • General Chemistry
  • General Biochemistry,Genetics and Molecular Biology
  • General Physics and Astronomy


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