Hampering stromal cells in the tumor microenvironment as a therapeutic strategy to destem cancer stem cells

Katherine Po Sin Chung, Rainbow Wing Hei Leung, Terence Kin Wah Lee

Research output: Journal article publicationReview articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

Cancer stem cells (CSCs) within the tumor bulk play crucial roles in tumor initiation, recurrence and therapeutic resistance. In addition to intrinsic regulation, a growing body of evidence suggests that the phenotypes of CSCs are also regulated extrinsically by stromal cells in the tumor microenvironment (TME). Here, we discuss the current knowledge of the interplay between stromal cells and cancer cells with a special focus on how stromal cells drive the stemness of cancer cells and immune evasive mechanisms of CSCs. Knowledge gained from the interaction between CSCs and stromal cells will provide a mechanistic basis for the development of novel therapeutic strategies for the treatment of cancers.

Original languageEnglish
Article number3191
JournalCancers
Volume13
Issue number13
DOIs
Publication statusPublished - 1 Jul 2021

Keywords

  • Cancer
  • Cancer stem cells
  • Immune cells
  • Stromal cells
  • Tumor microenvironment

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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