Abstract
Gui-ling-gao (GLG), also known as turtle/tortoise jelly, has been traditionally used as a functional food in southern China, Singapore, and Malaysia to regulate the immune system. In the present study, the antiinflammatory effects of GLG against Concanavalin A (Con A)-induced inflammation in BALB/c mice isolated splenocytes were evaluated. GLG significantly (p <.05) inhibited Con A-induced splenocyte proliferation in a concentration-dependent manner. Con A-mediated increases in mRNA and protein expressions of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) were suppressed by GLG treatment (p <.001). GLG decreased the upregulated mRNA expressions of interleukin-1β (IL-1β) (p <.05) and IL-15 (p <.001) induced by Con A. These findings suggest that GLG possesses potential antiinflammatory effects by inhibiting the expressions of iNOS and proinflammatory cytokines, such as TNF-α, IL-1β, and IL-15. Practical applications: The present study revealed that Gui-ling-gao (GLG) exhibited potential antiinflammatory effect. Thus, GLG could be employed as an effective health food for regulating immune system to cope with inflammation.
Original language | English |
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Article number | e12367 |
Journal | Journal of Food Biochemistry |
Volume | 41 |
Issue number | 4 |
DOIs | |
Publication status | Published - Aug 2017 |
Keywords
- antiinflammatory
- concanavalin A
- immune cells
- traditional Chinese functional food
- tumour necrosis factor-alpha
- turtle/tortoise jelly
ASJC Scopus subject areas
- Food Science
- Biophysics
- Pharmacology
- Cell Biology