Guasha-induced hepatoprotection in chronic active hepatitis B: A case study

Suk tak Chan, Wai Man Yuen, Mayur Danny I. Gohel, Chi ping Chung, Ho cheong Wong, Kenneth K. Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

21 Citations (Scopus)


Background: Heme oxygenase-1 (HO-1) has demonstrated hepatoprotective effect in animal hepatitis models. HO-1 was also reported to be upregulated with Guasha, an ancient therapeutic technique which applies instrument assisted press-stroking to treat many disorders. Methods: We report a case on the changes of liver function, plasma HO-1 and T-helper (Th) cytokine balance in a chronic active hepatitis B carrier before and after Guasha. The patient presented with increased activities of liver enzymes (ALT and AST), indicating inflammatory damage in liver before Guasha. Results: Forty-eight hours after receiving Guasha, the patient showed changes in a number of serum markers: a decline of liver enzymes (ALT and AST) indicating reduced chronic inflammation, an elevated plasma HO-1, and a modulation of T-helper (Th)1/Th2 balance. Conclusions: Guasha was shown to transiently reduce the inflammatory markers of liver injury in human, together with an enhancement of HO-1 which might be responsible for the hepatoprotective action.
Original languageEnglish
Pages (from-to)1686-1688
Number of pages3
JournalClinica Chimica Acta
Issue number17-18
Publication statusPublished - 17 Aug 2011


  • Guasha
  • Heme oxygenase
  • Hepatitis
  • Human

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical


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