Guanidine-containing double-network silks with enhanced tensile and antibacterial property

Chang Liu, Xin Hu, Xiang Zhou, Yan Ma, Polly H.M. Leung, John H. Xin, Bin Fei (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

The bacterial infection of surgical wounds results in prolonged hospitalization and even death of patients, calling for antibacterial function in modern suture products. To tackle this challenge, cationic guanidine-containing copolymer was synthesized, exhibiting antibacterial potency over 5 log reduction against both Gram-positive S. aureus and Gram-negative E. coli. Furthermore, we developed a double-network silk suture by integrating a guanidine-containing copolymer network into the silk fibroin network. This suture exhibited biocidal activity against S. aureus and E. coli, and superior strength compared to the commercial product in both dry and wet conditions. These results may bring general benefits to public health and medical equipment sustainability.

Original languageEnglish
Article number125470
JournalInternational Journal of Biological Macromolecules
Volume244
DOIs
Publication statusPublished - 31 Jul 2023

Keywords

  • Antibacterial property
  • Double networks
  • Silk suture

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology

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