Gold(III) porphyrins as a new class of anticancer drugs: Cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

Chi Ming Che; Raymond Wai Yin Sun; Wing Yiu Yu; Chi Bun Ko; Nianyong Zhu; Hongzhe Sun

Gold(III) porphyrins as a new class of anticancer drugs: Cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

Chi Ming Che
, Raymond Wai Yin Sun
, Wing Yiu Yu
, Chi Bun Ko
, Nianyong Zhu
, Hongzhe Sun

Research output: Journal article publication › Journal article › Academic research › peer-review

Abstract

A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.

Original language	English
Pages (from-to)	1718-1719
Number of pages	2
Journal	Chemical Communications
Volume	9
Issue number	14
Publication status	Published - 21 Jul 2003
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Cite this

@article{a62d986a26de41e0b48527d521fa3079,

title = "Gold(III) porphyrins as a new class of anticancer drugs: Cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells",

abstract = "A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.",

author = "Che, \{Chi Ming\} and Sun, \{Raymond Wai Yin\} and Yu, \{Wing Yiu\} and Ko, \{Chi Bun\} and Nianyong Zhu and Hongzhe Sun",

year = "2003",

month = jul,

day = "21",

language = "English",

volume = "9",

pages = "1718--1719",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "14",

}

Gold(III) porphyrins as a new class of anticancer drugs: Cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells. / Che, Chi Ming; Sun, Raymond Wai Yin; Yu, Wing Yiu et al.
In: Chemical Communications, Vol. 9, No. 14, 21.07.2003, p. 1718-1719.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - Gold(III) porphyrins as a new class of anticancer drugs: Cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

AU - Che, Chi Ming

AU - Sun, Raymond Wai Yin

AU - Yu, Wing Yiu

AU - Ko, Chi Bun

AU - Zhu, Nianyong

AU - Sun, Hongzhe

PY - 2003/7/21

Y1 - 2003/7/21

N2 - A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.

AB - A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.

UR - https://www.scopus.com/pages/publications/0038639859

M3 - Journal article

SN - 1359-7345

VL - 9

SP - 1718

EP - 1719

JO - Chemical Communications

JF - Chemical Communications

IS - 14

ER -

Gold(III) porphyrins as a new class of anticancer drugs: Cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

Abstract

UN SDGs

ASJC Scopus subject areas

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