Gold(III) porphyrins as a new class of anticancer drugs: Cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

Chi Ming Che; Raymond Wai Yin Sun; Wing Yiu Yu; Chi Bun Ko; Nianyong Zhu; Hongzhe Sun

Gold(III) porphyrins as a new class of anticancer drugs: Cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

Chi Ming Che, Raymond Wai Yin Sun, Wing Yiu Yu, Chi Bun Ko, Nianyong Zhu, Hongzhe Sun

Research output: Journal article publication › Journal article › Academic research › peer-review

Abstract

A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.

Original language	English
Pages (from-to)	1718-1719
Number of pages	2
Journal	Chemical Communications
Volume	9
Issue number	14
Publication status	Published - 21 Jul 2003
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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Cite this

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title = "Gold(III) porphyrins as a new class of anticancer drugs: Cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells",

abstract = "A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.",

author = "Che, {Chi Ming} and Sun, {Raymond Wai Yin} and Yu, {Wing Yiu} and Ko, {Chi Bun} and Nianyong Zhu and Hongzhe Sun",

year = "2003",

month = jul,

day = "21",

language = "English",

volume = "9",

pages = "1718--1719",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

number = "14",

}

Gold(III) porphyrins as a new class of anticancer drugs: Cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells. / Che, Chi Ming; Sun, Raymond Wai Yin; Yu, Wing Yiu ; Ko, Chi Bun; Zhu, Nianyong; Sun, Hongzhe.

In: Chemical Communications, Vol. 9, No. 14, 21.07.2003, p. 1718-1719.

Research output: Journal article publication › Journal article › Academic research › peer-review

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AU - Che, Chi Ming

AU - Sun, Raymond Wai Yin

AU - Yu, Wing Yiu

AU - Ko, Chi Bun

AU - Zhu, Nianyong

AU - Sun, Hongzhe

PY - 2003/7/21

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AB - A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.

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M3 - Journal article

VL - 9

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JO - Chemical Communications

JF - Chemical Communications

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IS - 14

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