Gold(III) porphyrins as a new class of anticancer drugs: Cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

Chi Ming Che, Raymond Wai Yin Sun, Wing Yiu Yu, Chi Bun Ko, Nianyong Zhu, Hongzhe Sun

Research output: Journal article publicationJournal articleAcademic researchpeer-review

223 Citations (Scopus)

Abstract

A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.
Original languageEnglish
Pages (from-to)1718-1719
Number of pages2
JournalChemical Communications
Volume9
Issue number14
Publication statusPublished - 21 Jul 2003
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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