Gold(III) porphyrin complex is more potent than cisplatin in inhibiting growth of nasopharyngeal carcinoma in vitro and in vivo

Fai To Yuk, Raymond Wai Yin Sun, Yongxiong Chen, Vera Sau Fong Chan, Wing Yiu Yu, Paul Kwong Hang Tam, Chi Ming Che, Chen Lung Steve Lin

Research output: Journal article publicationJournal articleAcademic researchpeer-review

69 Citations (Scopus)

Abstract

Nasopharyngeal carcinoma (NPC) is a common neoplasm in Southeastern Asia, and cisplatin-containing regimens for combinational chemotherapy are widely used for treating locally recurrent or metastatic diseases. However, resistance to cisplatin is not infrequently seen and its associated side effects may be life-threatening. In this report, another metallo-pharmaceutical agent gold(III) porphyrin complex [Au(TPP)]Cl was investigated in comparison to cisplatin for its in vitro and in vivo anticancer effects. Through induction of the intrinsic apoptosis pathway, [Au(TPP)]Cl exhibited 100-fold higher potency than cisplatin in killing NPC cells, including cisplatin-sensitive and cisplatin-resistant variants, and also an variant harboring the Epstein-Barr virus. In addition, a safety concentration window was demonstrated, allowing [Au(TPP)]Cl to kill tumors with minimal cytotoxicity to noncancerous cells. More importantly, weekly intraperitoneal injection of 3 mg/kg [Au(TPP)]Cl was more effective than the same dose of cisplatin in inducing tumor apoptosis in vivo and remarkably inhibited tumor growth in animals without any noticeable side effect. [Au(TPP)]Cl therefore is a promising chemotherapeutic agent that deserves further development as a novel drug for the treatment of advanced NPC, in particular, for cases with cisplatin-resistance.
Original languageEnglish
Pages (from-to)1971-1979
Number of pages9
JournalInternational Journal of Cancer
Volume124
Issue number8
DOIs
Publication statusPublished - 15 Apr 2009

Keywords

  • Chemotherapeutics
  • Cisplatin
  • Gold(III)
  • Nasopharyngeal carcinoma
  • Neoplasm
  • Porphyrin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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