Gold nanorods coated with multilayer polyelectrolyte as contrast agents for multimodal imaging

Hong Ding; Ken Tye Yong; Indrajit Roy; Haridas E. Pudavar; Wing Cheung Law; Earl J. Bergey; Paras N. Prasad

doi:10.1021/jp0733419

Gold nanorods coated with multilayer polyelectrolyte as contrast agents for multimodal imaging

Hong Ding, Ken Tye Yong, Indrajit Roy, Haridas E. Pudavar, Wing Cheung Law, Earl J. Bergey, Paras N. Prasad

Research output: Journal article publication › Journal article › Academic research › peer-review

216 Citations (Scopus)

Abstract

Gold nanorods coated with multilayer polyelectrolyte is reported as a biocompatible optical probe with capability for dark-field imaging and for electron microscopy of cancer cells. Transferrin (Tf) was conjugated to the polyelectrolyte-coated nanorods for targeted in vitro delivery to cancer cells. Dark-field imaging was used to confirm the receptor-mediated uptake of nanorods into HeLa cells, which is known to overexpress the transferrin receptor (TfR). Minimal uptake was observed with untargeted nanorods. Electron microscopy was used to confirm that the intracellular uptake of the nanorods predominantly occurred via the Tf-TfR interaction and the nanorods localized in vesicular structures such as endosomes.

Original language	English
Pages (from-to)	12552-12557
Number of pages	6
Journal	Journal of Physical Chemistry C
Volume	111
Issue number	34
DOIs	https://doi.org/10.1021/jp0733419
Publication status	Published - 30 Aug 2007
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Energy
Physical and Theoretical Chemistry
Surfaces, Coatings and Films

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1021/jp0733419

Cite this

@article{f605077bcaff42eaa6ad5ff8b43cd8c2,

title = "Gold nanorods coated with multilayer polyelectrolyte as contrast agents for multimodal imaging",

abstract = "Gold nanorods coated with multilayer polyelectrolyte is reported as a biocompatible optical probe with capability for dark-field imaging and for electron microscopy of cancer cells. Transferrin (Tf) was conjugated to the polyelectrolyte-coated nanorods for targeted in vitro delivery to cancer cells. Dark-field imaging was used to confirm the receptor-mediated uptake of nanorods into HeLa cells, which is known to overexpress the transferrin receptor (TfR). Minimal uptake was observed with untargeted nanorods. Electron microscopy was used to confirm that the intracellular uptake of the nanorods predominantly occurred via the Tf-TfR interaction and the nanorods localized in vesicular structures such as endosomes.",

author = "Hong Ding and Yong, {Ken Tye} and Indrajit Roy and Pudavar, {Haridas E.} and Law, {Wing Cheung} and Bergey, {Earl J.} and Prasad, {Paras N.}",

year = "2007",

month = aug,

day = "30",

doi = "10.1021/jp0733419",

language = "English",

volume = "111",

pages = "12552--12557",

journal = "Journal of Physical Chemistry C",

issn = "1932-7447",

publisher = "American Chemical Society",

number = "34",

}

TY - JOUR

T1 - Gold nanorods coated with multilayer polyelectrolyte as contrast agents for multimodal imaging

AU - Ding, Hong

AU - Yong, Ken Tye

AU - Roy, Indrajit

AU - Pudavar, Haridas E.

AU - Law, Wing Cheung

AU - Bergey, Earl J.

AU - Prasad, Paras N.

PY - 2007/8/30

Y1 - 2007/8/30

N2 - Gold nanorods coated with multilayer polyelectrolyte is reported as a biocompatible optical probe with capability for dark-field imaging and for electron microscopy of cancer cells. Transferrin (Tf) was conjugated to the polyelectrolyte-coated nanorods for targeted in vitro delivery to cancer cells. Dark-field imaging was used to confirm the receptor-mediated uptake of nanorods into HeLa cells, which is known to overexpress the transferrin receptor (TfR). Minimal uptake was observed with untargeted nanorods. Electron microscopy was used to confirm that the intracellular uptake of the nanorods predominantly occurred via the Tf-TfR interaction and the nanorods localized in vesicular structures such as endosomes.

AB - Gold nanorods coated with multilayer polyelectrolyte is reported as a biocompatible optical probe with capability for dark-field imaging and for electron microscopy of cancer cells. Transferrin (Tf) was conjugated to the polyelectrolyte-coated nanorods for targeted in vitro delivery to cancer cells. Dark-field imaging was used to confirm the receptor-mediated uptake of nanorods into HeLa cells, which is known to overexpress the transferrin receptor (TfR). Minimal uptake was observed with untargeted nanorods. Electron microscopy was used to confirm that the intracellular uptake of the nanorods predominantly occurred via the Tf-TfR interaction and the nanorods localized in vesicular structures such as endosomes.

UR - http://www.scopus.com/inward/record.url?scp=34548572162&partnerID=8YFLogxK

U2 - 10.1021/jp0733419

DO - 10.1021/jp0733419

M3 - Journal article

SN - 1932-7447

VL - 111

SP - 12552

EP - 12557

JO - Journal of Physical Chemistry C

JF - Journal of Physical Chemistry C

IS - 34

ER -

Gold nanorods coated with multilayer polyelectrolyte as contrast agents for multimodal imaging

Abstract

ASJC Scopus subject areas

UN SDGs

More information

Other files and links

Fingerprint

Cite this