Gold nanorods coated with multilayer polyelectrolyte as contrast agents for multimodal imaging

Hong Ding, Ken Tye Yong, Indrajit Roy, Haridas E. Pudavar, Wing Cheung Law, Earl J. Bergey, Paras N. Prasad

Research output: Journal article publicationJournal articleAcademic researchpeer-review

207 Citations (Scopus)

Abstract

Gold nanorods coated with multilayer polyelectrolyte is reported as a biocompatible optical probe with capability for dark-field imaging and for electron microscopy of cancer cells. Transferrin (Tf) was conjugated to the polyelectrolyte-coated nanorods for targeted in vitro delivery to cancer cells. Dark-field imaging was used to confirm the receptor-mediated uptake of nanorods into HeLa cells, which is known to overexpress the transferrin receptor (TfR). Minimal uptake was observed with untargeted nanorods. Electron microscopy was used to confirm that the intracellular uptake of the nanorods predominantly occurred via the Tf-TfR interaction and the nanorods localized in vesicular structures such as endosomes.
Original languageEnglish
Pages (from-to)12552-12557
Number of pages6
JournalJournal of Physical Chemistry C
Volume111
Issue number34
DOIs
Publication statusPublished - 30 Aug 2007
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Energy(all)
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films

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