Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys

Marco K. Wittmann (Corresponding Author), Elsa Fouragnan, Davide Folloni, Miriam C. Klein-Flügge, Bolton K.H. Chau, Mehdi Khamassi, Matthew F.S. Rushworth

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)

Abstract

People and other animals learn the values of choices by observing the contingencies between them and their outcomes. However, decisions are not guided by choice-linked reward associations alone; macaques also maintain a memory of the general, average reward rate – the global reward state – in an environment. Remarkably, global reward state affects the way that each choice outcome is valued and influences future decisions so that the impact of both choice success and failure is different in rich and poor environments. Successful choices are more likely to be repeated but this is especially the case in rich environments. Unsuccessful choices are more likely to be abandoned but this is especially likely in poor environments. Functional magnetic resonance imaging (fMRI) revealed two distinct patterns of activity, one in anterior insula and one in the dorsal raphe nucleus, that track global reward state as well as specific outcome events.

Original languageEnglish
Article number3771
JournalNature Communications
Volume11
Issue number1
DOIs
Publication statusPublished - 28 Jul 2020

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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