TY - JOUR
T1 - Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys
AU - Wittmann, Marco K.
AU - Fouragnan, Elsa
AU - Folloni, Davide
AU - Klein-Flügge, Miriam C.
AU - Chau, Bolton K.H.
AU - Khamassi, Mehdi
AU - Rushworth, Matthew F.S.
N1 - Funding Information:
This study was funded by the Wellcome Trust (WT100973AI; 203139/Z/16/Z; 105238/Z/ 14/Z) and MRC (MR/P024955/1; CQR01330) and a UKRI FLF to E.F. (MR/T023007/1). M.K. was funded by the Centre National de la Recherche Scientifique (Mission pour l’Interdisciplinarité). We thank Tim Behrens, Nils Kolling, Alizée Lopez-Persem, and Jacqueline Scholl for helpful discussions.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/7/28
Y1 - 2020/7/28
N2 - People and other animals learn the values of choices by observing the contingencies between them and their outcomes. However, decisions are not guided by choice-linked reward associations alone; macaques also maintain a memory of the general, average reward rate – the global reward state – in an environment. Remarkably, global reward state affects the way that each choice outcome is valued and influences future decisions so that the impact of both choice success and failure is different in rich and poor environments. Successful choices are more likely to be repeated but this is especially the case in rich environments. Unsuccessful choices are more likely to be abandoned but this is especially likely in poor environments. Functional magnetic resonance imaging (fMRI) revealed two distinct patterns of activity, one in anterior insula and one in the dorsal raphe nucleus, that track global reward state as well as specific outcome events.
AB - People and other animals learn the values of choices by observing the contingencies between them and their outcomes. However, decisions are not guided by choice-linked reward associations alone; macaques also maintain a memory of the general, average reward rate – the global reward state – in an environment. Remarkably, global reward state affects the way that each choice outcome is valued and influences future decisions so that the impact of both choice success and failure is different in rich and poor environments. Successful choices are more likely to be repeated but this is especially the case in rich environments. Unsuccessful choices are more likely to be abandoned but this is especially likely in poor environments. Functional magnetic resonance imaging (fMRI) revealed two distinct patterns of activity, one in anterior insula and one in the dorsal raphe nucleus, that track global reward state as well as specific outcome events.
UR - http://www.scopus.com/inward/record.url?scp=85088636470&partnerID=8YFLogxK
U2 - 10.1038/s41467-020-17343-w
DO - 10.1038/s41467-020-17343-w
M3 - Journal article
C2 - 32724052
AN - SCOPUS:85088636470
SN - 2041-1723
VL - 11
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 3771
ER -