Genome-wide linkage analysis of blood pressure under locus heterogeneity.

Xinqun Yang; Kai Wang; Jian Huang; Veronica J. Vieland

Genome-wide linkage analysis of blood pressure under locus heterogeneity.

Xinqun Yang, Kai Wang, Jian Huang, Veronica J. Vieland

Research output: Journal article publication › Journal article › Academic research › peer-review

Abstract

We describe a method for mapping quantitative trait loci that allows for locus heterogeneity. A genome-wide linkage analysis of blood pressure was performed using sib-pair data from the Framingham Heart Study. Evidence of linkage was found on four markers (GATA89G08, GATA23D06, GATA14E09, and 049xd2) at a significance level of 0.01. Two of them (GATA14E09 and 049xd2) seem to overlap with linkage signals reported previously, while the other two are not linked to any known signals.

Original language	English
Article number	S78
Journal	BMC Genetics
Volume	4 Suppl 1
Publication status	Published - 1 Dec 2003

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Cite this

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title = "Genome-wide linkage analysis of blood pressure under locus heterogeneity.",

abstract = "We describe a method for mapping quantitative trait loci that allows for locus heterogeneity. A genome-wide linkage analysis of blood pressure was performed using sib-pair data from the Framingham Heart Study. Evidence of linkage was found on four markers (GATA89G08, GATA23D06, GATA14E09, and 049xd2) at a significance level of 0.01. Two of them (GATA14E09 and 049xd2) seem to overlap with linkage signals reported previously, while the other two are not linked to any known signals.",

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year = "2003",

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T1 - Genome-wide linkage analysis of blood pressure under locus heterogeneity.

AU - Yang, Xinqun

AU - Wang, Kai

AU - Huang, Jian

AU - Vieland, Veronica J.

PY - 2003/12/1

Y1 - 2003/12/1

N2 - We describe a method for mapping quantitative trait loci that allows for locus heterogeneity. A genome-wide linkage analysis of blood pressure was performed using sib-pair data from the Framingham Heart Study. Evidence of linkage was found on four markers (GATA89G08, GATA23D06, GATA14E09, and 049xd2) at a significance level of 0.01. Two of them (GATA14E09 and 049xd2) seem to overlap with linkage signals reported previously, while the other two are not linked to any known signals.

AB - We describe a method for mapping quantitative trait loci that allows for locus heterogeneity. A genome-wide linkage analysis of blood pressure was performed using sib-pair data from the Framingham Heart Study. Evidence of linkage was found on four markers (GATA89G08, GATA23D06, GATA14E09, and 049xd2) at a significance level of 0.01. Two of them (GATA14E09 and 049xd2) seem to overlap with linkage signals reported previously, while the other two are not linked to any known signals.

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M3 - Journal article

C2 - 14975146

SN - 1471-2156

VL - 4 Suppl 1

JO - BMC Genetics

JF - BMC Genetics

M1 - S78

ER -

Genome-wide linkage analysis of blood pressure under locus heterogeneity.

Abstract

ASJC Scopus subject areas

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