Abstract
We report a genome-wide linkage study of asthma on the German and Collaborative Study on the Genetics of Asthma (CSGA) data. Using a combined linkage and linkage disequilibrium test and the nonparametric linkage score, we identified 13 markers from the German data, 1 marker from the African American (CSGA) data, and 7 markers from the Caucasian (CSGA) data in which the p-values ranged between 0.0001 and 0.0100. From our analysis and taking into account previous published linkage studies of asthma, we suggest that three regions in chromosome 5 (around D5S418, D5S644, and D5S422), one region in chromosome 6 (around three neighboring markers D6S1281, D6S291, and D6S1019), one region in chromosome 11 (around D11S2362), and two regions in chromosome 12 (around D12S351 and D12S324) especially merit further investigation.
| Original language | English |
|---|---|
| Journal | Genetic Epidemiology |
| Volume | 21 |
| Issue number | SUPPL. 1 |
| Publication status | Published - 23 Oct 2001 |
| Externally published | Yes |
Keywords
- Adaptive combination
- Linkage
- TDT
ASJC Scopus subject areas
- Epidemiology
- Genetics(clinical)