Genetic and functional characterization of blaCTX-M-199, a novel tazobactam and sulbactam resistance-encoding gene located in a conjugative mcr-1-bearing IncI2 plasmid

Jiachang Cai; Qipeng Cheng; Yingbo Shen; Danxia Gu; Ying Fang; Edward Wai Chi Chan; Sheng Chen

doi:10.1128/AAC.00562-17

Genetic and functional characterization of bla_CTX-M-199, a novel tazobactam and sulbactam resistance-encoding gene located in a conjugative mcr-1-bearing IncI2 plasmid

Jiachang Cai, Qipeng Cheng, Yingbo Shen, Danxia Gu, Ying Fang, Edward Wai Chi Chan, Sheng Chen

Research output: Journal article publication › Journal article › Academic research › peer-review

19 Citations (Scopus)

Abstract

We report the genetic and functional characterization of a novel CTX-M-199 β-lactamase, which was encoded by a blaCTX-M-64variant gene found in a conjugative mcr-1-bearing IncI2 plasmid and exhibited resistance to β-lactamase inhibitors, tazobactam, and sulbactam.

Original language	English
Article number	e00562-17
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00562-17
Publication status	Published - 1 Jul 2017

Keywords

Conjugative IncI2 plasmid
CTX-M-199
Enzyme kinetics
Function
Inhibitor resistance
mcr-1

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1128/AAC.00562-17

Cite this

@article{89979f7e836041c4b5cd0b9091993a49,

title = "Genetic and functional characterization of blaCTX-M-199, a novel tazobactam and sulbactam resistance-encoding gene located in a conjugative mcr-1-bearing IncI2 plasmid",

abstract = "We report the genetic and functional characterization of a novel CTX-M-199 β-lactamase, which was encoded by a blaCTX-M-64variant gene found in a conjugative mcr-1-bearing IncI2 plasmid and exhibited resistance to β-lactamase inhibitors, tazobactam, and sulbactam.",

keywords = "Conjugative IncI2 plasmid, CTX-M-199, Enzyme kinetics, Function, Inhibitor resistance, mcr-1",

author = "Jiachang Cai and Qipeng Cheng and Yingbo Shen and Danxia Gu and Ying Fang and Chan, {Edward Wai Chi} and Sheng Chen",

year = "2017",

month = jul,

day = "1",

doi = "10.1128/AAC.00562-17",

language = "English",

volume = "61",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "7",

}

Genetic and functional characterization of bla_CTX-M-199, a novel tazobactam and sulbactam resistance-encoding gene located in a conjugative mcr-1-bearing IncI2 plasmid. / Cai, Jiachang; Cheng, Qipeng; Shen, Yingbo et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 7, e00562-17, 01.07.2017.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - Genetic and functional characterization of blaCTX-M-199, a novel tazobactam and sulbactam resistance-encoding gene located in a conjugative mcr-1-bearing IncI2 plasmid

AU - Cai, Jiachang

AU - Cheng, Qipeng

AU - Shen, Yingbo

AU - Gu, Danxia

AU - Fang, Ying

AU - Chan, Edward Wai Chi

AU - Chen, Sheng

PY - 2017/7/1

Y1 - 2017/7/1

N2 - We report the genetic and functional characterization of a novel CTX-M-199 β-lactamase, which was encoded by a blaCTX-M-64variant gene found in a conjugative mcr-1-bearing IncI2 plasmid and exhibited resistance to β-lactamase inhibitors, tazobactam, and sulbactam.

AB - We report the genetic and functional characterization of a novel CTX-M-199 β-lactamase, which was encoded by a blaCTX-M-64variant gene found in a conjugative mcr-1-bearing IncI2 plasmid and exhibited resistance to β-lactamase inhibitors, tazobactam, and sulbactam.

KW - Conjugative IncI2 plasmid

KW - CTX-M-199

KW - Enzyme kinetics

KW - Function

KW - Inhibitor resistance

KW - mcr-1

UR - http://www.scopus.com/inward/record.url?scp=85021903563&partnerID=8YFLogxK

U2 - 10.1128/AAC.00562-17

DO - 10.1128/AAC.00562-17

M3 - Journal article

C2 - 28483954

SN - 0066-4804

VL - 61

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 7

M1 - e00562-17

ER -