Genetic and functional characterization of blaCTX-M-199, a novel tazobactam and sulbactam resistance-encoding gene located in a conjugative mcr-1-bearing IncI2 plasmid

Jiachang Cai, Qipeng Cheng, Yingbo Shen, Danxia Gu, Ying Fang, Edward Wai Chi Chan, Sheng Chen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

9 Citations (Scopus)

Abstract

We report the genetic and functional characterization of a novel CTX-M-199 β-lactamase, which was encoded by a blaCTX-M-64variant gene found in a conjugative mcr-1-bearing IncI2 plasmid and exhibited resistance to β-lactamase inhibitors, tazobactam, and sulbactam.
Original languageEnglish
Article numbere00562-17
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Conjugative IncI2 plasmid
  • CTX-M-199
  • Enzyme kinetics
  • Function
  • Inhibitor resistance
  • mcr-1

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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