Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

Jie Pan; Bethany I. Harriss; Chi Fai Chan; Lijun Jiang; Tik Hung Tsoi; Nicholas J. Long; Wing Tak Wong; Wai Kwok Wong; Ka Leung Wong

doi:10.1021/acs.inorgchem.6b01159

Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

Jie Pan
, Bethany I. Harriss
, Chi Fai Chan
, Lijun Jiang
, Tik Hung Tsoi
, Nicholas J. Long
, Wing Tak Wong
, Wai Kwok Wong
, Ka Leung Wong

Research output: Journal article publication › Journal article › Academic research › peer-review

15 Citations (Scopus)

Abstract

A water-soluble bimetallic normal ("cold") and radiochemical ("hot") gallium-porphyrin-ruthenium-bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields. ⁶⁸GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.

Original language	English
Pages (from-to)	6839-6841
Number of pages	3
Journal	Inorganic Chemistry
Volume	55
Issue number	14
DOIs	https://doi.org/10.1021/acs.inorgchem.6b01159 https://doi.org/10.1021/acs.inorgchem.6b01159
Publication status	Published - 18 Jul 2016

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry

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http://hdl.handle.net/10397/101607

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@article{0042a128f6a3499fb3af8f09b8feae4c,

title = "Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes",

abstract = "A water-soluble bimetallic normal ({"}cold{"}) and radiochemical ({"}hot{"}) gallium-porphyrin-ruthenium-bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85\%) yields. 68GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.",

author = "Jie Pan and Harriss, \{Bethany I.\} and Chan, \{Chi Fai\} and Lijun Jiang and Tsoi, \{Tik Hung\} and Long, \{Nicholas J.\} and Wong, \{Wing Tak\} and Wong, \{Wai Kwok\} and Wong, \{Ka Leung\}",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

year = "2016",

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doi = "10.1021/acs.inorgchem.6b01159",

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T1 - Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

AU - Pan, Jie

AU - Harriss, Bethany I.

AU - Chan, Chi Fai

AU - Jiang, Lijun

AU - Tsoi, Tik Hung

AU - Long, Nicholas J.

AU - Wong, Wing Tak

AU - Wong, Wai Kwok

AU - Wong, Ka Leung

PY - 2016/7/18

Y1 - 2016/7/18

N2 - A water-soluble bimetallic normal ("cold") and radiochemical ("hot") gallium-porphyrin-ruthenium-bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields. 68GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.

AB - A water-soluble bimetallic normal ("cold") and radiochemical ("hot") gallium-porphyrin-ruthenium-bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields. 68GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.

UR - https://www.scopus.com/pages/publications/84978709021

U2 - 10.1021/acs.inorgchem.6b01159

DO - 10.1021/acs.inorgchem.6b01159

M3 - Journal article

C2 - 27355871

SN - 0020-1669

VL - 55

SP - 6839

EP - 6841

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 14

ER -

Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

Abstract

ASJC Scopus subject areas

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