Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

Jie Pan; Bethany I. Harriss; Chi Fai Chan; Lijun Jiang; Tik Hung Tsoi; Nicholas J. Long; Wing Tak Wong; Wai Kwok Wong; Ka Leung Wong

doi:10.1021/acs.inorgchem.6b01159

Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

Jie Pan, Bethany I. Harriss, Chi Fai Chan, Lijun Jiang, Tik Hung Tsoi, Nicholas J. Long, Wing Tak Wong, Wai Kwok Wong, Ka Leung Wong

Research output: Journal article publication › Journal article › Academic research › peer-review

14 Citations (Scopus)

Abstract

A water-soluble bimetallic normal ("cold") and radiochemical ("hot") gallium-porphyrin-ruthenium-bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields.68GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.

Original language	English
Pages (from-to)	6839-6841
Number of pages	3
Journal	Inorganic Chemistry
Volume	55
Issue number	14
DOIs	https://doi.org/10.1021/acs.inorgchem.6b01159
Publication status	Published - 18 Jul 2016

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry

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10.1021/acs.inorgchem.6b01159

http://hdl.handle.net/10397/101607

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title = "Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes",

abstract = "A water-soluble bimetallic normal ({"}cold{"}) and radiochemical ({"}hot{"}) gallium-porphyrin-ruthenium-bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields.68GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.",

author = "Jie Pan and Harriss, {Bethany I.} and Chan, {Chi Fai} and Lijun Jiang and Tsoi, {Tik Hung} and Long, {Nicholas J.} and Wong, {Wing Tak} and Wong, {Wai Kwok} and Wong, {Ka Leung}",

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T1 - Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

AU - Pan, Jie

AU - Harriss, Bethany I.

AU - Chan, Chi Fai

AU - Jiang, Lijun

AU - Tsoi, Tik Hung

AU - Long, Nicholas J.

AU - Wong, Wing Tak

AU - Wong, Wai Kwok

AU - Wong, Ka Leung

PY - 2016/7/18

Y1 - 2016/7/18

N2 - A water-soluble bimetallic normal ("cold") and radiochemical ("hot") gallium-porphyrin-ruthenium-bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields.68GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.

AB - A water-soluble bimetallic normal ("cold") and radiochemical ("hot") gallium-porphyrin-ruthenium-bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields.68GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.

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U2 - 10.1021/acs.inorgchem.6b01159

DO - 10.1021/acs.inorgchem.6b01159

M3 - Journal article

C2 - 27355871

SN - 0020-1669

VL - 55

SP - 6839

EP - 6841

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 14

ER -

Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

Abstract

ASJC Scopus subject areas

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