Gallic acid suppresses cell viability, proliferation, invasion and angiogenesis in human glioma cells

Yong Lu, Feng Jiang, Hao Jiang, Kalina Wu, Xuguang Zheng, Yizhong Cai, Mark Katakowski, Michael Chopp, Shing Shun Tony To

Research output: Journal article publicationJournal articleAcademic researchpeer-review

151 Citations (Scopus)

Abstract

Gallic acid, an organic acid, also known as 3,4,5-trihydroxybenzoic acid, is cytotoxic against certain cancer cells, without harming normal cells. The objective of this study is to evaluate whether gallic acid can inhibit glioma cell viability, proliferation, invasion and reduce glioma cell mediated angiogenesis. Treatment of U87 and U251n glioma cells with gallic acid inhibited cell viability in a dose-dependent manner. BrdU and tube formation assays indicated that gallic acid significantly decreased glioma cell proliferation and tube formation in mouse brain endothelial cells, respectively. In addition, gallic acid decreased U87 cell invasion in vitro. Western blot analysis showed that expression of ADAM17, p-Akt and p-Erk was suppressed by gallic acid in both U87 and U251n cell lines. These data suggest that suppression of ADAM17 and downregulation of PI3K/Akt and Ras/MAPK signaling pathways may contribute to gallic acid-induced decrease of invasiveness. Gallic acid may be a valuable candidate for treatment of brain tumor.
Original languageEnglish
Pages (from-to)102-107
Number of pages6
JournalEuropean Journal of Pharmacology
Volume641
Issue number2-3
DOIs
Publication statusPublished - 1 Sep 2010

Keywords

  • Angiogenesis
  • Gallic acid
  • Glioma
  • Invasion
  • Proliferation

ASJC Scopus subject areas

  • Pharmacology

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