Gadolinium-porphyrin based polymer nanotheranostics for fluorescence/magnetic resonance imaging guided photodynamic therapy

Wandi Chen; Junkai Zhao; Mengfei Hou; Mo Yang; Changqing Yi

doi:10.1039/d1nr04489c

Gadolinium-porphyrin based polymer nanotheranostics for fluorescence/magnetic resonance imaging guided photodynamic therapy

Wandi Chen
, Junkai Zhao
, Mengfei Hou
, Mo Yang
, Changqing Yi

Research output: Journal article publication › Journal article › Academic research › peer-review

30 Citations (Scopus)

Abstract

Nanotheranostics for fluorescence/magnetic resonance (FL/MR) dual-modal imaging guided photodynamic therapy (PDT) are highly desirable in precision and personalized medicine. In this study, a facile non-covalent electrostatic interaction induced self-assembly strategy is developed to effectively encapsulate gadolinium porphyrin (Gd-TCPP) into homogeneous supramolecular nanoparticles (referred to as Gd-PNPs). Gd-PNPs exhibit the following advantages: (1) excellent FL imaging property, high longitudinal relaxivity (16.157 mM-1 s-1), and good singlet oxygen (1O2) production property; (2) excellent long-term colloidal stability, dispersity and biocompatibility; and (3) enhanced in vivo FL/MR imaging guided tumor growth inhibition efficiency for CT 26 tumor-bearing mice. This study provides a new strategy to design and synthesize metalloporphyrin-based nanotheranostics for imaging-guided cancer therapy with enhanced theranostic properties.

Original language	English
Pages (from-to)	16197-16206
Number of pages	10
Journal	Nanoscale
Volume	13
Issue number	38
DOIs	https://doi.org/10.1039/d1nr04489c
Publication status	Published - 14 Oct 2021

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

General Materials Science

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10.1039/d1nr04489c

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@article{eaf04126894448959d7787fa0ee55101,

title = "Gadolinium-porphyrin based polymer nanotheranostics for fluorescence/magnetic resonance imaging guided photodynamic therapy",

abstract = "Nanotheranostics for fluorescence/magnetic resonance (FL/MR) dual-modal imaging guided photodynamic therapy (PDT) are highly desirable in precision and personalized medicine. In this study, a facile non-covalent electrostatic interaction induced self-assembly strategy is developed to effectively encapsulate gadolinium porphyrin (Gd-TCPP) into homogeneous supramolecular nanoparticles (referred to as Gd-PNPs). Gd-PNPs exhibit the following advantages: (1) excellent FL imaging property, high longitudinal relaxivity (16.157 mM-1 s-1), and good singlet oxygen (1O2) production property; (2) excellent long-term colloidal stability, dispersity and biocompatibility; and (3) enhanced in vivo FL/MR imaging guided tumor growth inhibition efficiency for CT 26 tumor-bearing mice. This study provides a new strategy to design and synthesize metalloporphyrin-based nanotheranostics for imaging-guided cancer therapy with enhanced theranostic properties.",

author = "Wandi Chen and Junkai Zhao and Mengfei Hou and Mo Yang and Changqing Yi",

note = "Funding Information: The financial support from the Guangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instruments (2020B1212060077) and the Guangdong Natural Science Foundation (S2017A030313076 and 2020A1515010661) is gratefully acknowledged. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2021",

month = oct,

day = "14",

doi = "10.1039/d1nr04489c",

language = "English",

volume = "13",

pages = "16197--16206",

journal = "Nanoscale",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Gadolinium-porphyrin based polymer nanotheranostics for fluorescence/magnetic resonance imaging guided photodynamic therapy

AU - Chen, Wandi

AU - Zhao, Junkai

AU - Hou, Mengfei

AU - Yang, Mo

AU - Yi, Changqing

N1 - Funding Information: The financial support from the Guangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instruments (2020B1212060077) and the Guangdong Natural Science Foundation (S2017A030313076 and 2020A1515010661) is gratefully acknowledged. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2021/10/14

Y1 - 2021/10/14

N2 - Nanotheranostics for fluorescence/magnetic resonance (FL/MR) dual-modal imaging guided photodynamic therapy (PDT) are highly desirable in precision and personalized medicine. In this study, a facile non-covalent electrostatic interaction induced self-assembly strategy is developed to effectively encapsulate gadolinium porphyrin (Gd-TCPP) into homogeneous supramolecular nanoparticles (referred to as Gd-PNPs). Gd-PNPs exhibit the following advantages: (1) excellent FL imaging property, high longitudinal relaxivity (16.157 mM-1 s-1), and good singlet oxygen (1O2) production property; (2) excellent long-term colloidal stability, dispersity and biocompatibility; and (3) enhanced in vivo FL/MR imaging guided tumor growth inhibition efficiency for CT 26 tumor-bearing mice. This study provides a new strategy to design and synthesize metalloporphyrin-based nanotheranostics for imaging-guided cancer therapy with enhanced theranostic properties.

AB - Nanotheranostics for fluorescence/magnetic resonance (FL/MR) dual-modal imaging guided photodynamic therapy (PDT) are highly desirable in precision and personalized medicine. In this study, a facile non-covalent electrostatic interaction induced self-assembly strategy is developed to effectively encapsulate gadolinium porphyrin (Gd-TCPP) into homogeneous supramolecular nanoparticles (referred to as Gd-PNPs). Gd-PNPs exhibit the following advantages: (1) excellent FL imaging property, high longitudinal relaxivity (16.157 mM-1 s-1), and good singlet oxygen (1O2) production property; (2) excellent long-term colloidal stability, dispersity and biocompatibility; and (3) enhanced in vivo FL/MR imaging guided tumor growth inhibition efficiency for CT 26 tumor-bearing mice. This study provides a new strategy to design and synthesize metalloporphyrin-based nanotheranostics for imaging-guided cancer therapy with enhanced theranostic properties.

UR - https://www.scopus.com/pages/publications/85116880096

U2 - 10.1039/d1nr04489c

DO - 10.1039/d1nr04489c

M3 - Journal article

C2 - 34545903

AN - SCOPUS:85116880096

SN - 2040-3364

VL - 13

SP - 16197

EP - 16206

JO - Nanoscale

JF - Nanoscale

IS - 38

ER -

Gadolinium-porphyrin based polymer nanotheranostics for fluorescence/magnetic resonance imaging guided photodynamic therapy

Abstract

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