@article{d75be9244d0d44cb8bb110739934f3f5,
title = "Gadolinium and platinum in tandem: Real-time multi-modal monitoring of drug delivery by mri and fluorescence imaging",
abstract = "A novel dual-imaging cisplatin-carrying molecular cargo capable of performing simultaneous optical and MR imaging is reported herein. This long-lasting MRI contrast agent (r1 relaxivity of 23.4 mM-1s-1 at 3T, 25o C) is a photo-activated cisplatin prodrug (PtGdL) which enables real-time monitoring of anti-cancer efficacy. PtGdL is a model for monitoring the drug delivery and anti-cancer efficacy by MRI with a much longer retention time (24 hours) in several organs such as renal cortex and spleen than GdDOTA and its motif control GdL. Upon complete release of cisplatin, all PtGdL is converted to GdL enabling subsequent MRI analyses of therapy efficacy within its reasonably short clearance time of 4 hours. There is also responsive fluorescence enhancement for monitoring by photon-excitation.",
keywords = "Cisplatin, Drug delivery, Fluorescence imaging, MRI, Multi-modal, Prodrug",
author = "Hongguang Li and Harriss, {Bethany I.} and Alkystis Phinikaridou and Sara Lacerda and Gregory Ramniceanu and Doan, {Bich Thuy} and Ho, {Ka Lok} and Chan, {Chi Fai} and Lo, {Wai Sum} and Botnar, {Ren{\'e} M.} and Rongfeng Lan and Cyrille Richard and Law, {Ga Lai} and Long, {Nicholas J.} and Wong, {Ka Leung}",
note = "Funding Information: This work is funded by the Hong Kong Baptist University (FRG2/15-16/009), PNCORE (F-HKBU203/14), Hong Kong Polytechnic University (HKPolyU), Hong Kong Research Grants Council (HKBU 12309516), Hong Kong Polytechnic University central Research Grant (G-UC08), HKBU-HKPolyU Joint Research Programme (RC-ICRS/15-16/02F-WKL02F-WKL) and a Royal Society International Exchange grant, Institut Weizmann Fran?ais Grant, CNRS, IDEX Programme interdisciplinaire, Universit? Paris Descartes and PHC PROCORE (project 33122PA). Funding Information: This work is funded by the Hong Kong Baptist University (FRG2/15-16/009), PNCORE (F-HKBU203/14), Hong Kong Polytechnic University (HKPolyU), Hong Kong Research Grants Council (HKBU 12309516), Hong Kong Polytechnic University central Research Grant (G-UC08), HKBU-HKPolyU Joint Research Programme (RC-ICRS/15-16/02F-WKL02F-WKL) and a Royal Society International Exchange grant, Institut Weizmann Fran{\c c}ais Grant, CNRS, IDEX Programme interdisciplinaire, Universit{\'e} Paris Descartes and PHC PROCORE (project 33122PA). Publisher Copyright: {\textcopyright} Ivyspring International Publisher.",
year = "2017",
doi = "10.7150/ntno.18619",
language = "English",
volume = "1",
pages = "186--195",
journal = "Nanotheranostics",
issn = "2206-7418",
publisher = "Ivyspring International Publishers",
number = "2",
}
