Functional connectivity differences in speech production networks in Chinese children with Rolandic epilepsy

Yun Wu; Fang Fang; Ke Li; Zhen Jin; Xiaotun Ren; Junlan Lv; Changhong Ding; Chunhong Chen; Tongli Han; Weihua Zhang; Nizhuan Wang; Zhenglong Lin

doi:10.1016/j.yebeh.2022.108819

Functional connectivity differences in speech production networks in Chinese children with Rolandic epilepsy

Yun Wu, Fang Fang, Ke Li, Zhen Jin, Xiaotun Ren, Junlan Lv, Changhong Ding, Chunhong Chen, Tongli Han, Weihua Zhang, Nizhuan Wang, Zhenglong Lin (Corresponding Author)

Research output: Journal article publication › Journal article › Academic research › peer-review

8 Citations (Scopus)

Abstract

Previous studies have demonstrated that language impairments are frequently observed in patients with benign epilepsy with centrotemporal spikes (BECTS). However, how BECTS affects language processing in the Chinese population remains unclear. With the use of functional magnetic resonance imaging (fMRI) in an overt picture-naming task, the present study examined functional connectivity in 27 children with BECTS and 26 healthy controls. The results indicated that children with BECTS showed altered functional connectivity associated with speech production between the left precuneus and the right cerebellum, between the right precuneus and the bilateral thalamus and the left superior temporal gyrus, between the right cuneus and the right postcentral gyrus and the right inferior parietal lobule, and between the right cerebellum and right middle frontal gyrus. Collectively, the findings in this study demonstrate the abnormal functional connectivity basis of speech production in Chinese children with BECTS, providing clues to understanding the brain mechanisms of language-related network in patients with BECTS.

Original language	English
Article number	108819
Journal	Epilepsy and Behavior
Volume	135
Early online date	12 Jul 2022
DOIs	https://doi.org/10.1016/j.yebeh.2022.108819
Publication status	Published - Oct 2022
Externally published	Yes

Keywords

Brain activation
Childhood epilepsy with centrotemporal spikes
fMRI
Functional connectivity

ASJC Scopus subject areas

Neurology
Clinical Neurology
Behavioral Neuroscience

More information

10.1016/j.yebeh.2022.108819

Cite this

@article{d7bd63c996ad4f8f930f69212016be4d,

title = "Functional connectivity differences in speech production networks in Chinese children with Rolandic epilepsy",

abstract = "Previous studies have demonstrated that language impairments are frequently observed in patients with benign epilepsy with centrotemporal spikes (BECTS). However, how BECTS affects language processing in the Chinese population remains unclear. With the use of functional magnetic resonance imaging (fMRI) in an overt picture-naming task, the present study examined functional connectivity in 27 children with BECTS and 26 healthy controls. The results indicated that children with BECTS showed altered functional connectivity associated with speech production between the left precuneus and the right cerebellum, between the right precuneus and the bilateral thalamus and the left superior temporal gyrus, between the right cuneus and the right postcentral gyrus and the right inferior parietal lobule, and between the right cerebellum and right middle frontal gyrus. Collectively, the findings in this study demonstrate the abnormal functional connectivity basis of speech production in Chinese children with BECTS, providing clues to understanding the brain mechanisms of language-related network in patients with BECTS.",

keywords = "Brain activation, Childhood epilepsy with centrotemporal spikes, fMRI, Functional connectivity",

author = "Yun Wu and Fang Fang and Ke Li and Zhen Jin and Xiaotun Ren and Junlan Lv and Changhong Ding and Chunhong Chen and Tongli Han and Weihua Zhang and Nizhuan Wang and Zhenglong Lin",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = oct,

doi = "10.1016/j.yebeh.2022.108819",

language = "English",

volume = "135",

journal = "Epilepsy and Behavior",

issn = "1525-5050",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Functional connectivity differences in speech production networks in Chinese children with Rolandic epilepsy

AU - Wu, Yun

AU - Fang, Fang

AU - Li, Ke

AU - Jin, Zhen

AU - Ren, Xiaotun

AU - Lv, Junlan

AU - Ding, Changhong

AU - Chen, Chunhong

AU - Han, Tongli

AU - Zhang, Weihua

AU - Wang, Nizhuan

AU - Lin, Zhenglong

PY - 2022/10

Y1 - 2022/10

N2 - Previous studies have demonstrated that language impairments are frequently observed in patients with benign epilepsy with centrotemporal spikes (BECTS). However, how BECTS affects language processing in the Chinese population remains unclear. With the use of functional magnetic resonance imaging (fMRI) in an overt picture-naming task, the present study examined functional connectivity in 27 children with BECTS and 26 healthy controls. The results indicated that children with BECTS showed altered functional connectivity associated with speech production between the left precuneus and the right cerebellum, between the right precuneus and the bilateral thalamus and the left superior temporal gyrus, between the right cuneus and the right postcentral gyrus and the right inferior parietal lobule, and between the right cerebellum and right middle frontal gyrus. Collectively, the findings in this study demonstrate the abnormal functional connectivity basis of speech production in Chinese children with BECTS, providing clues to understanding the brain mechanisms of language-related network in patients with BECTS.

AB - Previous studies have demonstrated that language impairments are frequently observed in patients with benign epilepsy with centrotemporal spikes (BECTS). However, how BECTS affects language processing in the Chinese population remains unclear. With the use of functional magnetic resonance imaging (fMRI) in an overt picture-naming task, the present study examined functional connectivity in 27 children with BECTS and 26 healthy controls. The results indicated that children with BECTS showed altered functional connectivity associated with speech production between the left precuneus and the right cerebellum, between the right precuneus and the bilateral thalamus and the left superior temporal gyrus, between the right cuneus and the right postcentral gyrus and the right inferior parietal lobule, and between the right cerebellum and right middle frontal gyrus. Collectively, the findings in this study demonstrate the abnormal functional connectivity basis of speech production in Chinese children with BECTS, providing clues to understanding the brain mechanisms of language-related network in patients with BECTS.

KW - Brain activation

KW - Childhood epilepsy with centrotemporal spikes

KW - fMRI

KW - Functional connectivity

UR - http://www.scopus.com/inward/record.url?scp=85134359733&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2022.108819

DO - 10.1016/j.yebeh.2022.108819

M3 - Journal article

C2 - 35835716

AN - SCOPUS:85134359733

SN - 1525-5050

VL - 135

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

M1 - 108819

ER -

Functional connectivity differences in speech production networks in Chinese children with Rolandic epilepsy

Abstract

Keywords

ASJC Scopus subject areas

More information

Other files and links

Fingerprint

Cite this