Abstract
Full enzymatic synthesis of a fragment of osteogenic growth peptide (OGP), a precursor of bioactive pentapeptide OGP(10-14) (Z-TyrGlyPheGlyGlyOEt), was accomplished by papain, α-chymotrypsin, and thermolysin via 2+3 or 3+2 synthetic routes in organic solvents for the first time. The factors influencing the enzymatic synthesis of fragments of OGP(10-14) were systematically studied.
Original language | English |
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Pages (from-to) | 2423-2425 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 43 |
Issue number | 13 |
DOIs | |
Publication status | Published - 25 Mar 2002 |
Keywords
- Full enzymatic synthesis
- OGP(10-14)
- Organic solvent
- Protease
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry