Full enzymatic synthesis of a precursor of bioactive pentapeptide OGP(10-14) in organic solvents

Ping Liu; Gui Ling Tian; Kin Sing Lee; Man Sau Wong; Yun Hua Ye

doi:10.1016/S0040-4039(02)00278-2

Full enzymatic synthesis of a precursor of bioactive pentapeptide OGP(10-14) in organic solvents

Ping Liu, Gui Ling Tian, Kin Sing Lee, Man Sau Wong, Yun Hua Ye

Research output: Journal article publication › Journal article › Academic research › peer-review

23 Citations (Scopus)

Abstract

Full enzymatic synthesis of a fragment of osteogenic growth peptide (OGP), a precursor of bioactive pentapeptide OGP(10-14) (Z-TyrGlyPheGlyGlyOEt), was accomplished by papain, α-chymotrypsin, and thermolysin via 2+3 or 3+2 synthetic routes in organic solvents for the first time. The factors influencing the enzymatic synthesis of fragments of OGP(10-14) were systematically studied.

Original language	English
Pages (from-to)	2423-2425
Number of pages	3
Journal	Tetrahedron Letters
Volume	43
Issue number	13
DOIs	https://doi.org/10.1016/S0040-4039(02)00278-2
Publication status	Published - 25 Mar 2002

Keywords

Full enzymatic synthesis
OGP(10-14)
Organic solvent
Protease

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

More information

10.1016/S0040-4039(02)00278-2

Cite this

@article{7aef5589c4d24a0e82a21fbbdd5a3b73,

title = "Full enzymatic synthesis of a precursor of bioactive pentapeptide OGP(10-14) in organic solvents",

abstract = "Full enzymatic synthesis of a fragment of osteogenic growth peptide (OGP), a precursor of bioactive pentapeptide OGP(10-14) (Z-TyrGlyPheGlyGlyOEt), was accomplished by papain, α-chymotrypsin, and thermolysin via 2+3 or 3+2 synthetic routes in organic solvents for the first time. The factors influencing the enzymatic synthesis of fragments of OGP(10-14) were systematically studied.",

keywords = "Full enzymatic synthesis, OGP(10-14), Organic solvent, Protease",

author = "Ping Liu and Tian, {Gui Ling} and Lee, {Kin Sing} and Wong, {Man Sau} and Ye, {Yun Hua}",

year = "2002",

month = mar,

day = "25",

doi = "10.1016/S0040-4039(02)00278-2",

language = "English",

volume = "43",

pages = "2423--2425",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "13",

}

TY - JOUR

T1 - Full enzymatic synthesis of a precursor of bioactive pentapeptide OGP(10-14) in organic solvents

AU - Liu, Ping

AU - Tian, Gui Ling

AU - Lee, Kin Sing

AU - Wong, Man Sau

AU - Ye, Yun Hua

PY - 2002/3/25

Y1 - 2002/3/25

N2 - Full enzymatic synthesis of a fragment of osteogenic growth peptide (OGP), a precursor of bioactive pentapeptide OGP(10-14) (Z-TyrGlyPheGlyGlyOEt), was accomplished by papain, α-chymotrypsin, and thermolysin via 2+3 or 3+2 synthetic routes in organic solvents for the first time. The factors influencing the enzymatic synthesis of fragments of OGP(10-14) were systematically studied.

AB - Full enzymatic synthesis of a fragment of osteogenic growth peptide (OGP), a precursor of bioactive pentapeptide OGP(10-14) (Z-TyrGlyPheGlyGlyOEt), was accomplished by papain, α-chymotrypsin, and thermolysin via 2+3 or 3+2 synthetic routes in organic solvents for the first time. The factors influencing the enzymatic synthesis of fragments of OGP(10-14) were systematically studied.

KW - Full enzymatic synthesis

KW - OGP(10-14)

KW - Organic solvent

KW - Protease

UR - http://www.scopus.com/inward/record.url?scp=0037170582&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(02)00278-2

DO - 10.1016/S0040-4039(02)00278-2

M3 - Journal article

VL - 43

SP - 2423

EP - 2425

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 13

ER -