Full enzymatic synthesis of a precursor of bioactive pentapeptide OGP(10-14) in organic solvents

Ping Liu, Gui Ling Tian, Kin Sing Lee, Man Sau Wong, Yun Hua Ye

Research output: Journal article publicationJournal articleAcademic researchpeer-review

23 Citations (Scopus)

Abstract

Full enzymatic synthesis of a fragment of osteogenic growth peptide (OGP), a precursor of bioactive pentapeptide OGP(10-14) (Z-TyrGlyPheGlyGlyOEt), was accomplished by papain, α-chymotrypsin, and thermolysin via 2+3 or 3+2 synthetic routes in organic solvents for the first time. The factors influencing the enzymatic synthesis of fragments of OGP(10-14) were systematically studied.
Original languageEnglish
Pages (from-to)2423-2425
Number of pages3
JournalTetrahedron Letters
Volume43
Issue number13
DOIs
Publication statusPublished - 25 Mar 2002

Keywords

  • Full enzymatic synthesis
  • OGP(10-14)
  • Organic solvent
  • Protease

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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