Freeze-drying of aqueous solution frozen with prebuilt pores

Wei Wang, Dapeng Hu, Yanqiu Pan, Yanqiang Zhao, Guohua Chen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

28 Citations (Scopus)


To save drying time and increase productivity, a novel idea was proposed for freeze-drying of liquid materials by creating an initially unsaturated frozen structure. An experimental investigation was carried out aiming at verifying the idea using a multifunctional freeze-drying apparatus. Mannitol was selected as the primary solute in aqueous solution. Liquid nitrogen ice-cream making method was used to prepare the frozen materials with different initial porosities. Results show that freeze-drying can be significantly enhanced with the initially unsaturated frozen material, and substantial drying time can be saved compared with conventional freeze-drying of the initially saturated one. Drying time was found to decrease with the decrease in the initial saturation. The drying time for the initially unsaturated frozen sample (S0=0.28 or 0.69 of initial porosity) can be at best 32% shorter than that required for the saturated one (S0=1.00 or zero porosity). This unique technique is easy to implement and improves the freeze-drying performance of liquid materials.
Original languageEnglish
Pages (from-to)2048-2057
Number of pages10
JournalAICHE Journal
Issue number6
Publication statusPublished - 1 Jan 2015
Externally publishedYes


  • Freeze-drying
  • Initial saturation
  • Liquid material
  • Prebuilt pore
  • Unsaturated

ASJC Scopus subject areas

  • Biotechnology
  • Environmental Engineering
  • Chemical Engineering(all)


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