Four new isoflavonoids from the stem bark of Erythrina variegata

Li Xiaoli, Wang Naili, Man Sau Wong, Albert S C Chen, Yao Xinsheng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

26 Citations (Scopus)

Abstract

Bioassay-directed fractionation of the stem bark extract of Erythrina variegata L. has resulted in the isolation of three new isoflavones: 5,4′-dihydroxy-8-(3,3-dimethylallyl)-2″-methoxyisopropylfurano[4,5: 6,7]isoflavone (1), 5,7,4′-trihydroxy-6-(3,3-dimethylallyloxiranylmethyl) isoflavone (2), 5,4′-dihydroxy-8-(3,3-dimethylallyl)-2″- hydroxymethyl-2″-methylpyrano[5,6:6,7]isoflavone (3) and a new isoflavanone, 5,4′-dihydroxy-2′-methoxy-8-(3,3-dimethylallyl)- 2″,2″-dimethylpyrano[5,6:6,7]isoflavanone (4) together with seven known compounds, euchrenone b10 (5), isoerysenegalensein E (6), wighteone (7), laburnetin (8), lupiwighteone (9), erythrodiol (10), and oleanolic acid (11). The structures were determined on the basis of spectroscopic analyses and chemical evidence. The effect of these compounds on the proliferation of rat osteogenic sarcoma (UMR106) is also reported.
Original languageEnglish
Pages (from-to)570-573
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume54
Issue number4
DOIs
Publication statusPublished - 1 Apr 2006

Keywords

  • Erythrina variegata
  • Isoflavone
  • Leguminosae
  • UMR106 cell

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

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