Focusing light in scattering media by ultrasonically encoded wavefront shaping (SEWS)

Jian Wei Tay, Puxiang Lai, Yuta Suzuki, Lihong V. Wang

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review


Wavefront distortion in scattering media can be compensated for using optical wavefront shaping. In this technique, a spatial light modulator (SLM) is used to apply a spatially distributed phase shift to the optical field. A genetic optimization algorithm was used to obtain the SLM pattern which best focuses light within the medium. The target volume is defined by using a focused ultrasound beam to encode light travelling within the acoustic focus. The ultrasonically-encoded light is measured and used as feedback to the algorithm, which then searches for the pattern which maximizes the encoded light intensity. We call this technique ultrasonically-encoded wavefront shaping (SEWS). Using SEWS, we focused light into a scattering medium consisting of ground glass diffuser and a gelatin phantom. The optical intensity at the target was increased by 11 times over the original intensity. These results were validated using fluorescent imaging at the ultrasonic focus.
Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2014
ISBN (Print)9780819498564
Publication statusPublished - 1 Jan 2014
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2014 - San Francisco, CA, United States
Duration: 2 Feb 20145 Feb 2014


ConferencePhotons Plus Ultrasound: Imaging and Sensing 2014
Country/TerritoryUnited States
CitySan Francisco, CA


  • Imaging
  • Optical Engineering
  • Spatial Light Modulator
  • Turbidity Compensation
  • Ultrasound
  • Wavefront Shaping

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Focusing light in scattering media by ultrasonically encoded wavefront shaping (SEWS)'. Together they form a unique fingerprint.

Cite this