Fluorogenic Protein Labeling by Generation of Fluorescent Quinoliziniums Using [Cp*RhCl2]2

Ajcharapan Tantipanjaporn, Karen Ka Yan Kung, Man Kin Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

6 Citations (Scopus)


Fluorogenic labeling has received considerable attention as a result of the high demand in chemical biology and synthetic biology applications. Herein, we develop a new strategy for fluorescent turn-on ligation targeting alkyne- and quinoline-linked peptides and proteins (λem of 515 nm and up to φF of 0.20) using the [Cp*RhCl2]2 catalyst. The good conversion, high flexibility, broad utility, ease of use, and mild reaction conditions are great advantages to extend the rhodium-mediated turn-on fluorogenic bioconjugation for further applications.

Original languageEnglish
Pages (from-to)5835-5839
Number of pages5
JournalOrganic Letters
Issue number31
Publication statusPublished - 12 Aug 2022

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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