First synthesis of naturally occurring (±)-epi-conocarpan

Shi Long Zheng, Wing Yiu Yu, Ming Xia Xu, Chi Ming Che

Research output: Journal article publicationJournal articleAcademic researchpeer-review

37 Citations (Scopus)


(±)-epi-Conocarpan 1 was synthesized via the key intermediate 5-bromo-cis-2-(4-methoxyphenyl)-3-methyl-2,3-dihydrobenzofuran 6 which was synthesized by a ruthenium(II) porphyrin-catalyzed intramolecular C-H insertion reaction using aryl tosylhydrazone salt 5 as the carbene source, starting from the commercially available 5-bromo-2-hydroxyacetophenone.
Original languageEnglish
Pages (from-to)1445-1447
Number of pages3
JournalTetrahedron Letters
Issue number7
Publication statusPublished - 10 Feb 2003


  • (±)-epi-conocarpan
  • cis-2,3-dihydrobenzofuran
  • Intramolecular C-H insertion
  • Ruthenium(II) porphyrin

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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