FeSe2-Decorated Bi2Se3 Nanosheets Fabricated svia Cation Exchange for Chelator-Free 64Cu-Labeling and Multimodal Image-Guided Photothermal-Radiation Therapy

Liang Cheng, Sida D. Shen, Sixiang Shi, Yuan Yi, Xiaoyong Y. Wang, Guo Sheng Song, Kai Yang, Gang Liu, Todd E. Barnhart, Weibo B. Cai, Zhuang Liu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

188 Citations (Scopus)


Multifunctional theranostic agents have become rather attractive to realize image-guided combination cancer therapy. Herein, a novel method is developed to synthesize Bi2Se3 nanosheets decorated with mono-dispersed FeSe2 nanoparticles (FeSe2/Bi2Se3) for tetra-modal image-guided combined photothermal and radiation tumor therapy. Interestingly, upon addition of Bi(NO3)3, pre-made FeSe2 nanoparticles via cation exchange would be gradually converted into Bi2Se3 nanosheets, on which remaining FeSe2 nanoparticles are decorated. The yielded FeSe2/Bi2Se3 composite-nanostructures are then modified with polyethylene glycol (PEG). Taking advantages of the high r 2 relaxivity of FeSe2, the X-ray attenuation ability of Bi2Se3, the strong near-infrared optical absorbance of the whole nanostructure, as well as the chelate-free radiolabeling of 64Cu on FeSe2/Bi2Se3-PEG, in vivo magnetic resonance/computer tomography/photoacoustic/position emission tomography multimodal imaging is carried out, revealing efficient tumor homing of FeSe2/Bi2Se3-PEG after intravenous injection. Utilizing the intrinsic physical properties of FeSe2/Bi2Se3-PEG, in vivo photothermal and radiation therapy to achieve synergistic tumor destruction is then realized, without causing obvious toxicity to the treated animals. This work presents a unique method to synthesize composite-nanostructures with highly integrated functionalities, promising not only for nano-biomedicine but also potentially for other different nanotechnology fields.

Original languageEnglish
Pages (from-to)2185-2197
Number of pages13
JournalAdvanced Functional Materials
Issue number13
Early online date8 Feb 2016
Publication statusPublished - 5 Apr 2016
Externally publishedYes


  • cation exchange
  • chelator-free radiolabeling
  • FeSe/BiSe nanostructures
  • multimodal imaging
  • photothermal-radiation therapy treatment

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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