Fast water-exchange Gd3+-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivo

Cong Li; Ying Xia Li; Ga Lai Law; Kwan Man; Wing Tak Wong; Hao Lei

doi:10.1021/bc060003m

Fast water-exchange Gd³⁺-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivo

Cong Li, Ying Xia Li, Ga Lai Law, Kwan Man, Wing Tak Wong, Hao Lei

Research output: Journal article publication › Journal article › Academic research › peer-review

25 Citations (Scopus)

Abstract

A bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k ex = 3.1 × 107 s-1) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic.

Original language	English
Pages (from-to)	571-574
Number of pages	4
Journal	Bioconjugate Chemistry
Volume	17
Issue number	3
DOIs	https://doi.org/10.1021/bc060003m
Publication status	Published - 1 May 2006
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering
Pharmacology
Pharmaceutical Science
Organic Chemistry

More information

10.1021/bc060003m

Cite this

@article{ddce72fca77a4f888d5b592b372d2ca4,

title = "Fast water-exchange Gd3+-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivo",

abstract = "A bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k ex = 3.1 × 107 s-1) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic.",

author = "Cong Li and Li, {Ying Xia} and Law, {Ga Lai} and Kwan Man and Wong, {Wing Tak} and Hao Lei",

year = "2006",

month = may,

day = "1",

doi = "10.1021/bc060003m",

language = "English",

volume = "17",

pages = "571--574",

journal = "Bioconjugate Chemistry",

issn = "1043-1802",

publisher = "American Chemical Society",

number = "3",

}

TY - JOUR

T1 - Fast water-exchange Gd3+-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivo

AU - Li, Cong

AU - Li, Ying Xia

AU - Law, Ga Lai

AU - Man, Kwan

AU - Wong, Wing Tak

AU - Lei, Hao

PY - 2006/5/1

Y1 - 2006/5/1

N2 - A bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k ex = 3.1 × 107 s-1) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic.

AB - A bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k ex = 3.1 × 107 s-1) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic.

UR - http://www.scopus.com/inward/record.url?scp=33646928338&partnerID=8YFLogxK

U2 - 10.1021/bc060003m

DO - 10.1021/bc060003m

M3 - Journal article

C2 - 16704192

SN - 1043-1802

VL - 17

SP - 571

EP - 574

JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

IS - 3

ER -

Fast water-exchange Gd³⁺-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivo

Abstract

ASJC Scopus subject areas

More information

Other files and links

Fingerprint

Cite this