Fast localized single cell membrane poration by bubble-induced jetting flow

Z. G. Li, C. D. Ohl, J. B. Zhang, J. Tsai, A. Q. Liu

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

1 Citation (Scopus)

Abstract

This paper demonstrates a new method to porate single suspension living cell membrane using cavitation bubble-induced high speed jet flow. A microfluidic chip with an array of single cell trapping structures is designed and fabricated to trap sing cell and induce the asymmetric collapse of the cavitation bubble. Myeloma cells suspended in Trypan blue saline solution is tested and single Myeloma cells can be trapped in the trapping structures. The dynamic process is recorded using a high speed camera. This method has great potential in biomedical applications and easy to be integrated to other microfluidic system.

Original languageEnglish
Title of host publication2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Pages819-822
Number of pages4
DOIs
Publication statusPublished - Feb 2012
Externally publishedYes
Event2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 - Paris, France
Duration: 29 Jan 20122 Feb 2012

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Conference

Conference2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Country/TerritoryFrance
CityParis
Period29/01/122/02/12

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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