Family exposure and the impact of containment measures to children with coronavirus disease 2019 outside Hubei, China: a cross-sectional study

Shu Yang, Xixi Feng, Peipei Du, Daihai He, Janne Estill, Lin Yang, Chuanbiao Wen, Jiawei Luo, Xiaohui Wang, Liqun Lu, Tingting Li, Xiujuan Tang, Weiguo Li, Hongmei Xu, Enmei Liu, Peihua Cao, Yaolong Chen

Research output: Journal article publicationReview articleAcademic researchpeer-review


Background: In response to the ongoing epidemic of coronavirus disease 2019 (COVID-19), China has carried out restrictive disease containment measures across the country. Methods: In this cross-sectional study, we collected demographic and epidemiological data of 376 laboratory-confirmed cases of COVID-19 among children younger than 18 years of age. Using descriptive statistics and odds ratios, we described the odds of exposure outside the family after the implementation of control measures compared to before. Results: Children diagnosed on or after February 4, 2020, had a lower odds of exposure to COVID-19 outside of the family compared to those diagnosed before February 3, 2020 (OR =0.594, 95% CI: 0.391 to 0.904). In the stratified analysis, children aged 0 to 5 years had the lowest odds of exposure outside of the family (OR =0.420, 95% CI: 0.196 to 0.904) compared to the other age groups assessed. Conclusions: Our study on the children infected with COVID-19 as well as their exposure within family provided evidence that the implementation of containment measures was effective in reducing the odds of exposure outside of the family, especially for preschool children. Continuation of these efforts, coupled with tailored prevention and health education messaging for younger aged children, may help to reduce the transmission of COVID-19 among children until other therapeutic interventions or vaccines are available.

Original languageEnglish
Pages (from-to)92-102
Number of pages11
JournalTranslational Pediatrics
Issue number1
Publication statusPublished - Jan 2021


  • Children
  • Containment measures
  • Coronavirus
  • COVID-19
  • Family exposure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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