Facile one-pot synthesis of cyclic peptide-conjugated photosensitisers for targeted photodynamic therapy

Jacky C.H. Chu, Caixia Yang, Wing Ping Fong, Clarence T.T. Wong, Dennis K.P. Ng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

A novel synthetic strategy forin situcyclisation of peptides and conjugation with functional boron dipyrromethenes (BODIPYs) has been developed. Linear peptides with up to 16 amino acid residues can be cyclised effectively and the resulting conjugates can be isolated in higher than 20% yield. One of the conjugates having a cyclic RGD moiety has been studied bothin vitroandin vivo. It exhibits high and selective affinity towards the αvβ3-positive cell lines and induces high photocytotoxicity. The conjugate can also selectively localise in and effectively inhibit the growth of αvβ3-overexpressed tumourin vivo.

Original languageEnglish
Pages (from-to)11941-11944
Number of pages4
JournalChemical Communications
Volume56
Issue number80
DOIs
Publication statusPublished - 14 Oct 2020
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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