简易一锅合成新型5-取代P,O-型吲哚膦配体及其应用于钯催化芳基氯Suzuki-Miyaura偶联反应

Translated title of the contribution: Facile One-Pot Assembly of New 5-Substituted P,O-Type Indolylphosphine Ligands for Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Aryl Chlorides

Man Pan Leung, Chung Chiu Yeung, Pui Ying Choy, Chau Ming So, Fuk Yee Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

A series of P,O-type indolylphosphine ligands with different substituted variants have been synthesized by a simple one-pot protocol from readily available and inexpensive materials. These ligands show "substituent effect" with respected to the efficacy in promoting palladium-catalyzed Suzuki-Miyaura cross-coupling of aryl chlorides. This new Pd/L1 catalyst system particularly allows the catalyst loading reaching the level of 0.01 mol% Pd.

Translated title of the contributionFacile One-Pot Assembly of New 5-Substituted P,O-Type Indolylphosphine Ligands for Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Aryl Chlorides
Original languageChinese (Simplified)
Pages (from-to)3338-3346
Number of pages9
JournalChinese Journal of Organic Chemistry
Volume40
Issue number10
DOIs
Publication statusPublished - 1 Oct 2020

Keywords

  • Cross-coupling
  • Ligand design
  • P,O-ligand
  • Palladium
  • Phosphine

ASJC Scopus subject areas

  • Organic Chemistry

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