TY - JOUR
T1 - Fabrication of multifunctional polydopamine-coated gold nanobones for PA/CT imaging and enhanced synergistic chemo-photothermal therapy
AU - Xu, Jingwei
AU - Cheng, Xiaju
AU - Chen, Fuxian
AU - Li, Weijie
AU - Xiao, Xiaohui
AU - Lai, Puxiang
AU - Xu, Guopeng
AU - Xu, Li
AU - Pan, Yue
N1 - Funding Information:
This work was financially supported by the National Key R&D Program of China (No. 2018YFB1105700 ), the National Natural Science Foundation of China (Nos. 81902913 , 81930048 and 81627805 ), the Guangdong Basic and Applied Basic Research Foundation for Distinguished Young Scholars (No. 2020B1515020027 ), the Fundamental Research Funds for the Central Universities (No. 19ykpy108 ), the Natural Science Foundation of Jiangsu Province (No. BK20190821 ), the Postdoctoral Science Foundation of China (No. 2019M651953 ), the Open Project Program of the State Key Laboratory of Radiation Medicine and Protection, Soochow University (No. GZK1201909 ), the Guangdong Science and Technology Department (No. 2020B1212060018), the Science and Technology Project from Suzhou City Commission of Health and Family Planning (No. LCZX201712 ), the grants from Guangzhou Science and Technology Bureau ( 202002020070 , 201902020015 ), Opening Foundation of Hubei Province Key Laboratory of Molecular Imaging , and a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions .
Publisher Copyright:
© 2020
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/2/10
Y1 - 2021/2/10
N2 - Multimodal imaging-guided chemo-photothermal therapy is an excellent cancer treatment, which can not only efficiently against tumor, but also can offer precise treatment window and real-time monitoring of the treatment efficiency. In our work, polydopamine (PDA)-coated gold nanobones (AuNBs@PDA nanocomplexes) were designed for this approach. The AuNBs@PDA nanocomplexes have strong absorbance in the near infrared (NIR) region and higher photothermal conversion efficiency (75.48 %) than gold nanobones alone, which was facilitated for photoacoustic imaging and photothermal therapy. Besides, the loading efficiency of doxorubicin (DOX) by AuNBs@PDA nanocomplexes could be up to about 70 % and DOX release from AuNBs@PDA/DOX nanocomplexes sensitively response to the lower pH environment and NIR laser irradiation, which makes them become the excellent nano-carrier for the delivery of chemotherapy drug. In vitro and in vivo studies showed significant cytotoxicity and antitumor efficacy by the AuNBs@PDA/DOX nanoplatform with negligible side effects. Meanwhile, the nanoplatform was also successfully employed for computed tomography (CT) imaging, attributing to the high atomic number and high X-ray attenuation coefficient of gold. Therefore, we believed that the proposed PDA-coated gold nanobones would be a novel multifunctional theranostic nanoagent to realize the PA/CT imaging-guided chemo-photothermal therapy of cancer.
AB - Multimodal imaging-guided chemo-photothermal therapy is an excellent cancer treatment, which can not only efficiently against tumor, but also can offer precise treatment window and real-time monitoring of the treatment efficiency. In our work, polydopamine (PDA)-coated gold nanobones (AuNBs@PDA nanocomplexes) were designed for this approach. The AuNBs@PDA nanocomplexes have strong absorbance in the near infrared (NIR) region and higher photothermal conversion efficiency (75.48 %) than gold nanobones alone, which was facilitated for photoacoustic imaging and photothermal therapy. Besides, the loading efficiency of doxorubicin (DOX) by AuNBs@PDA nanocomplexes could be up to about 70 % and DOX release from AuNBs@PDA/DOX nanocomplexes sensitively response to the lower pH environment and NIR laser irradiation, which makes them become the excellent nano-carrier for the delivery of chemotherapy drug. In vitro and in vivo studies showed significant cytotoxicity and antitumor efficacy by the AuNBs@PDA/DOX nanoplatform with negligible side effects. Meanwhile, the nanoplatform was also successfully employed for computed tomography (CT) imaging, attributing to the high atomic number and high X-ray attenuation coefficient of gold. Therefore, we believed that the proposed PDA-coated gold nanobones would be a novel multifunctional theranostic nanoagent to realize the PA/CT imaging-guided chemo-photothermal therapy of cancer.
KW - Imaging
KW - Multifunctional nanobones
KW - Photothermal therapy
UR - http://www.scopus.com/inward/record.url?scp=85090830318&partnerID=8YFLogxK
U2 - 10.1016/j.jmst.2020.04.060
DO - 10.1016/j.jmst.2020.04.060
M3 - Journal article
AN - SCOPUS:85090830318
SN - 1005-0302
VL - 63
SP - 97
EP - 105
JO - Journal of Materials Science and Technology
JF - Journal of Materials Science and Technology
ER -
