Fabrication and characterization of poly-d-l-lactide/nano-hydroxyapatite composite scaffolds with poly (ethylene glycol) coating and dexamethasone releasing

L. Chen; Chak Yin Tang; D. Z. Chen; C. T. Wong; Chi Pong Tsui

doi:10.1016/j.compscitech.2011.08.015

Fabrication and characterization of poly-d-l-lactide/nano-hydroxyapatite composite scaffolds with poly (ethylene glycol) coating and dexamethasone releasing

L. Chen, Chak Yin Tang, D. Z. Chen, C. T. Wong, Chi Pong Tsui

Research output: Journal article publication › Journal article › Academic research › peer-review

35 Citations (Scopus)

Abstract

The control of pore size and structure, drug release capacity, and biodegradation of scaffolds is of importance for bone tissue engineering. In this study, a technique combining polymer coagulation, cold compression molding, salt particulate leaching and drug coating method was developed to fabricate poly (ethylene glycol)/dexamethasone coated porous poly-d-l-lactide/nano-hydroxyapatite (PDLLA/nano-HAp) scaffolds. These scaffolds possess homogenous pore networks with high porosity (66-82%) and controllable pore size (200-300μm). The compressive moduli and strength of the scaffolds after incorporation of nano-HAp were improved by 50% and 20%, respectively. The surface hydrophilicity of the scaffold was significantly improved by poly (ethylene glycol)/dexamethasone coating and nano-HAp addition, leading to a higher initial drug loading amount. The results showed that the drug release behavior of the scaffolds after 35-day immersion in water could be adjusted by varying the porosity level and by incorporation of 20 wt% of nano-HAp.

Original language	English
Pages (from-to)	1842-1849
Number of pages	8
Journal	Composites Science and Technology
Volume	71
Issue number	16
DOIs	https://doi.org/10.1016/j.compscitech.2011.08.015
Publication status	Published - 14 Nov 2011

Keywords

B. Porosity/Voids
B. Surface treatments
E. Casting

ASJC Scopus subject areas

Ceramics and Composites
General Engineering

More information

10.1016/j.compscitech.2011.08.015

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title = "Fabrication and characterization of poly-d-l-lactide/nano-hydroxyapatite composite scaffolds with poly (ethylene glycol) coating and dexamethasone releasing",

abstract = "The control of pore size and structure, drug release capacity, and biodegradation of scaffolds is of importance for bone tissue engineering. In this study, a technique combining polymer coagulation, cold compression molding, salt particulate leaching and drug coating method was developed to fabricate poly (ethylene glycol)/dexamethasone coated porous poly-d-l-lactide/nano-hydroxyapatite (PDLLA/nano-HAp) scaffolds. These scaffolds possess homogenous pore networks with high porosity (66-82%) and controllable pore size (200-300μm). The compressive moduli and strength of the scaffolds after incorporation of nano-HAp were improved by 50% and 20%, respectively. The surface hydrophilicity of the scaffold was significantly improved by poly (ethylene glycol)/dexamethasone coating and nano-HAp addition, leading to a higher initial drug loading amount. The results showed that the drug release behavior of the scaffolds after 35-day immersion in water could be adjusted by varying the porosity level and by incorporation of 20 wt% of nano-HAp.",

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Fabrication and characterization of poly-d-l-lactide/nano-hydroxyapatite composite scaffolds with poly (ethylene glycol) coating and dexamethasone releasing. / Chen, L.; Tang, Chak Yin; Chen, D. Z. et al.
In: Composites Science and Technology, Vol. 71, No. 16, 14.11.2011, p. 1842-1849.

Research output: Journal article publication › Journal article › Academic research › peer-review

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AU - Chen, L.

AU - Tang, Chak Yin

AU - Chen, D. Z.

AU - Wong, C. T.

AU - Tsui, Chi Pong

PY - 2011/11/14

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AB - The control of pore size and structure, drug release capacity, and biodegradation of scaffolds is of importance for bone tissue engineering. In this study, a technique combining polymer coagulation, cold compression molding, salt particulate leaching and drug coating method was developed to fabricate poly (ethylene glycol)/dexamethasone coated porous poly-d-l-lactide/nano-hydroxyapatite (PDLLA/nano-HAp) scaffolds. These scaffolds possess homogenous pore networks with high porosity (66-82%) and controllable pore size (200-300μm). The compressive moduli and strength of the scaffolds after incorporation of nano-HAp were improved by 50% and 20%, respectively. The surface hydrophilicity of the scaffold was significantly improved by poly (ethylene glycol)/dexamethasone coating and nano-HAp addition, leading to a higher initial drug loading amount. The results showed that the drug release behavior of the scaffolds after 35-day immersion in water could be adjusted by varying the porosity level and by incorporation of 20 wt% of nano-HAp.

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Fabrication and characterization of poly-d-l-lactide/nano-hydroxyapatite composite scaffolds with poly (ethylene glycol) coating and dexamethasone releasing

Abstract

Keywords

ASJC Scopus subject areas

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