Fabrication and characterization of poly-d-l-lactide/nano-hydroxyapatite composite scaffolds with poly (ethylene glycol) coating and dexamethasone releasing

L. Chen, Chak Yin Tang, D. Z. Chen, C. T. Wong, Chi Pong Tsui

Research output: Journal article publicationJournal articleAcademic researchpeer-review

31 Citations (Scopus)

Abstract

The control of pore size and structure, drug release capacity, and biodegradation of scaffolds is of importance for bone tissue engineering. In this study, a technique combining polymer coagulation, cold compression molding, salt particulate leaching and drug coating method was developed to fabricate poly (ethylene glycol)/dexamethasone coated porous poly-d-l-lactide/nano-hydroxyapatite (PDLLA/nano-HAp) scaffolds. These scaffolds possess homogenous pore networks with high porosity (66-82%) and controllable pore size (200-300μm). The compressive moduli and strength of the scaffolds after incorporation of nano-HAp were improved by 50% and 20%, respectively. The surface hydrophilicity of the scaffold was significantly improved by poly (ethylene glycol)/dexamethasone coating and nano-HAp addition, leading to a higher initial drug loading amount. The results showed that the drug release behavior of the scaffolds after 35-day immersion in water could be adjusted by varying the porosity level and by incorporation of 20 wt% of nano-HAp.
Original languageEnglish
Pages (from-to)1842-1849
Number of pages8
JournalComposites Science and Technology
Volume71
Issue number16
DOIs
Publication statusPublished - 14 Nov 2011

Keywords

  • B. Porosity/Voids
  • B. Surface treatments
  • E. Casting

ASJC Scopus subject areas

  • Ceramics and Composites
  • Engineering(all)

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